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The development of ...
The development of blood protein profiles in extremely preterm infants follows a stereotypic evolution pattern
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- Zhong, Wen (författare)
- Linköping University,Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Karolinska Inst, Sweden
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- Danielsson, Hanna (författare)
- Karolinska Institutet
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- Brusselaers, Nele (författare)
- Karolinska Institutet,Karolinska Inst, Sweden; Antwerp Univ, Belgium,University of Antwerp
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- Wackernagel, Dirk (författare)
- Karolinska Univ Hosp & Inst, Astrid Lindgrens Childrens Hosp, Dept Neonatol, Stockholm, Sweden.,Karolinska University Hospital
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- Sjöbom, Ulrika (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska Academy,Institutionen för vårdvetenskap och hälsa,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Health and Care Sciences,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Sävman, Karin, 1960 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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- Hansen Pupp, Ingrid (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatalogi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups,Skåne University Hospital
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- Ley, David (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatalogi,Forskargrupper vid Lunds universitet,LTH profilområde: Avancerade ljuskällor,LTH profilområden,Lunds Tekniska Högskola,LU profilområde: Ljus och material,Lunds universitets profilområden,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups,LTH Profile Area: Photon Science and Technology,LTH Profile areas,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas,Skåne University Hospital
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- Nilsson, Anders K., 1982 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Fagerberg, Linn (författare)
- KTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,KTH Royal Inst Technol, Sweden
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- Uhlén, Mathias (författare)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,Karolinska Inst, Dept Neurosci, Stockholm, Sweden.,Karolinska Inst, Sweden; KTH Royal Inst Technol, Sweden
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- Hellström, Ann (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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(creator_code:org_t)
- Springer Nature, 2023
- 2023
- Engelska.
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Ingår i: Communications Medicine. - : Springer Nature. - 2730-664X. ; 3:1
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Abstract
Ämnesord
Stäng
- BackgroundPreterm birth is the leading cause of neonatal mortality and morbidity. Early diagnosis and interventions are critical to improving the clinical outcomes of extremely premature infants. Blood protein profiling during the first months of life in preterm infants can shed light on the role of early extrauterine development and provide an increased understanding of maturation after extremely preterm birth and the underlying mechanisms of prematurity-related disorders.MethodsWe have investigated the blood protein profiles during the first months of life in preterm infants on the role of early extrauterine development. The blood protein levels were analyzed using next generation blood profiling on 1335 serum samples, collected longitudinally at nine time points from birth to full-term from 182 extremely preterm infants.ResultsThe protein analysis reveals evident predestined serum evolution patterns common for all included infants. The majority of the variations in blood protein expression are associated with the postnatal age of the preterm infants rather than any other factors. There is a uniform protein pattern on postnatal day 1 and after 30 weeks postmenstrual age (PMA), independent of gestational age (GA). However, during the first month of life, GA had a significant impact on protein variability.ConclusionsThe unified pattern of protein development for all included infants suggests an age-dependent stereotypic development of blood proteins after birth. This knowledge should be considered in neonatal settings and might alter the clinical approach within neonatology, where PMA is today the most dominant age variable.Plain language summaryBeing born too early can affect a baby's health. We looked at how babies born extremely preterm, meaning more than 12 weeks earlier than a full-term baby, develop. We looked at the proteins present in their blood from the day they were born until their original due date. Our study of 182 extremely preterm babies born at different points in the pregnancy (gestational ages) found that the proteins present in their blood changed in a similar way over time. This means that the age of a baby after birth, and not how early they were born, mostly affects the proteins in their blood. These findings help us understand how extremely preterm babies develop after birth, which could lead to improvements to their healthcare during the first few weeks of their life. Zhong, Danielsson et al. longitudinally profile the serum proteome in a cohort of extremely preterm infants. They identify a postnatal time-dependent stereotypic pattern of development in the blood proteome from premature birth to term-equivalent age.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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Zhong, Wen
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Danielsson, Hann ...
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Brusselaers, Nel ...
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Wackernagel, Dir ...
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Sjöbom, Ulrika
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Sävman, Karin, 1 ...
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Hansen Pupp, Ing ...
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Ley, David
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Nilsson, Anders ...
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Fagerberg, Linn
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Uhlén, Mathias
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Hellström, Ann
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Bioinformatik oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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Communications M ...
- Av lärosätet
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Kungliga Tekniska Högskolan
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Karolinska Institutet
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Linköpings universitet
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Lunds universitet
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Göteborgs universitet