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Oxidative, Genotoxi...
Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds
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- Oguzkan, Sibel Bayil (författare)
- Department of Medical Services and Techniques, Vocational School of Health Services, University of Gaziantep, Gaziantep, 27410, Turkey
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- Turkez, Hasan (författare)
- Department of Medical Biology, Faculty of Medicine, Atatürk University, Erzurum 25040, Turkey;
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- Ugras, Halil Ibrahim (författare)
- Department of Chemistry, Arts and Science Faculty, Düzce University, Düzce, 81620, Turkey
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- Tatar, Arzu (författare)
- Department of Otorhinolaryngology Diseases, Faculty of Medicine, Atatürk University, Erzurum 25040, Turkey;
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- Mardinoglu, Adil (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, London, WC2R 2LS, UK
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(creator_code:org_t)
- MDPI AG, 2023
- 2023
- Engelska.
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Ingår i: Inorganics. - : MDPI AG. - 2304-6740. ; 11:8
- Relaterad länk:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- In this study, the biological properties of novel borenium and borinium compounds in terms of their oxidative, genotoxic, and cytotoxic effects were assessed on cultured human peripheral blood cells, as well as several types of cancer cells. Our results revealed that the borinium compounds yielded the best results in terms of supporting total antioxidant capacity (TAC). In fact, borenium 1, borenium 2, borenium 3, borinium 4, and borinium 5 compounds elevated TAC levels of cultured human blood cells at rates of 42.8%, 101.5%, 69.8%, 33.3%, and 49.2%, respectively. There were no statistically significant differences (p > 0.05) between the negative control and the groups treated with all borinium and borenium concentrations from the micronucleus (MN) and chromosome aberration (CA) assays, demonstrating the non-genotoxic effects. Moreover, borenium 1 (60.7% and 50.7%), borenium 2 (70.4% and 57.2%), borenium 3 (53.1% and 45.2%), borinium 4 (55.1% and 48.1%), and borinium 5 (51.0% and 36.1%) minimized the mitomycin C(MMC)-induced genotoxic damages at different rates as determined using CA and MN assays, respectively. Again, it was found that the borinium compounds exhibited higher cytotoxic activity on cancer cells when compared to borenium compounds. Consequently, in light of our in vitro findings, it was suggested that the novel borinium and borenium compounds could be used safely in pharmacology, cosmetics, and various medical fields due to their antioxidant and non-genotoxic features, as well as their cytotoxicity potential on cancer cells.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- antigenotoxicity
- antioxidant
- borenium
- borinium
- boron compounds
- cancer cells
- cytotoxicity
- genotoxicity
- human blood cells
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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