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A novel noble metal...
A novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation : a blinded study
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- Sandell, Mikael (författare)
- KTH,Mikro- och nanosystemteknik,Department of Clinical Neuroscience, Karolinska Institute, Tomtebodavägen 18A, 171 77, Stockholm, Sweden, Tomtebodavägen 18A; MedTechLabs, Stockholm, Sweden
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- Ericsson, Anna (författare)
- Bactiguard AB, Alfred Nobels allé 150, 146 48, Tullinge, Sweden, Alfred Nobels allé 150
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- Al-Saadi, Jonathan (författare)
- Department of Clinical Neuroscience, Karolinska Institute, Tomtebodavägen 18A, 171 77, Stockholm, Sweden, Tomtebodavägen 18A
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- Södervall, Billy (författare)
- Bactiguard AB, Alfred Nobels allé 150, 146 48, Tullinge, Sweden, Alfred Nobels allé 150
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- Södergren, Erika (författare)
- Bactiguard AB, Alfred Nobels allé 150, 146 48, Tullinge, Sweden, Alfred Nobels allé 150
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- Grass, Stefan (författare)
- Bactiguard AB, Alfred Nobels allé 150, 146 48, Tullinge, Sweden, Alfred Nobels allé 150
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- Sanchez, Javier (författare)
- Bactiguard AB, Alfred Nobels allé 150, 146 48, Tullinge, Sweden, Alfred Nobels allé 150; Department of Clinical Sciences, Danderyd Hospital, 182 88, Stockholm, Sweden
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- Holmin, Staffan (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Springer Nature, 2023
- 2023
- Engelska.
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 13:1
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Inherent to any stenting procedure is the prescription of dual antiplatelet therapy (DAPT) to reduce the platelet response. Clinical guidelines recommend 6–12 months of DAPT, depending on stent type, clinical picture and patient factors. Our hypothesis is that a nanostructured noble metal coating has the potential to reduce protein deposition and platelet activation. These effects would reduce subsequent thrombo-inflammatory reactions, potentially mitigating the need for an extensive DAPT in the acute phase. Here, a noble metal nanostructure coating on stents is investigated. Twelve pigs underwent endovascular implantation of coated and non-coated stents for paired comparisons in a blinded study design. The non-coated control stent was placed at the contralateral corresponding artery. Volumetric analysis of angiographic data, performed by a treatment blinded assessor, demonstrated a significant thrombus reduction for one of the coatings compared to control. This effect was already seen one hour after implantation. This finding was supported by in vitro data showing a significant reduction of coagulation activation in the coated group. This novel coating shows promise as an implant material addition and could potentially decrease the need for DAPT in the early phases of stent implementation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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