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Multivariable robus...
Multivariable robust tube-based nonlinear model predictive control of mammalian cell cultures
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- Dewasme, Laurent (författare)
- Systems, Estimation, Control and Optimization (SECO) Group, Faculty of Engineering, University of Mons, 31, Boulevard Dolez, 7000 Mons, Belgium
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- Mäkinen, Meeri (författare)
- KTH,Industriell bioteknologi,Centre for Advanced BioProduction by Continuous Processing, AdBIOPRO
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- Chotteau, Véronique, Docent, 1963- (författare)
- KTH,Industriell bioteknologi,Centre for Advanced BioProduction by Continuous Processing, AdBIOPRO,Cell Technology group
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(creator_code:org_t)
- Elsevier BV, 2024
- 2024
- Engelska.
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Ingår i: Computers and Chemical Engineering. - : Elsevier BV. - 0098-1354 .- 1873-4375. ; 183
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- In this paper, the application of a robust nonlinear model predictive control (NMPC) framework to mammalian cell cultures is proposed, dealing with possible large kinetic parameter uncertainties. Industrial constraints formulated in view of good manufacturing practice and quality-by-design approach are also considered, namely the assurance that all state trajectories are contained within a corridor defined by lower and upper safety bounds. The latter are assimilated to the well-known tube-based paradigm which is used to formulate the corresponding robust NMPC problem. Both classical and tube-based NMPC performances are assessed in numerical simulations where specific key-species are regulated while dealing with an uncertain plant model. The capability of the tube-based method to reduce the impact of the parameter variations on the state trajectories and the violation of the constraints is highlighted, suggesting the transfer of the method on a real pharmaceutical process.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Elektroteknik och elektronik -- Reglerteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Electrical Engineering, Electronic Engineering, Information Engineering -- Control Engineering (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Bioprocessteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Bioprocess Technology (hsv//eng)
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