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Mechanistic study o...
Mechanistic study of transcription factor Sox18 during heart development
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- Liang, Jianxin (författare)
- School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
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- Ul Hassan, Imtiaz (författare)
- School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
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- Yee Cheung, Man (författare)
- School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
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- Feng, Lei (författare)
- School of Life Sciences and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China; Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Sciences, South China Normal University, Guangzhou, China
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- Lin, Yi jyun (författare)
- School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
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- Long, Qi (författare)
- School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
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- Wang, Chengdong (författare)
- School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
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- Ding, Yuyue (författare)
- School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
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- Wang, Ziqing (författare)
- School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
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- Zhang, Yuan (författare)
- School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
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- Li, Yulong (författare)
- School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
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- Guo, Donghao (författare)
- School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
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- Guo, Xiaofang (författare)
- School of Life Sciences, Jinan University, Guangzhou, China
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- Chi Bun Wong, Thomas (författare)
- School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
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- Kaleem Samma, Muhammad (författare)
- Department of Biology and Chemistry, City University of Hong Kong, Hong Kong SAR, China
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- Rong, Zixin (författare)
- KTH,Genteknologi
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- Qi, Xufeng (författare)
- School of Life Sciences, Jinan University, Guangzhou, China
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- Cai, Dongqing (författare)
- School of Life Sciences, Jinan University, Guangzhou, China
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- Ngai, Sai Ming (författare)
- School of Life Sciences and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China
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- Zhao, Hui (författare)
- School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
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(creator_code:org_t)
- Elsevier BV, 2024
- 2024
- Engelska.
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Ingår i: General and Comparative Endocrinology. - : Elsevier BV. - 0016-6480 .- 1095-6840. ; 350
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Heart development is a delicate and complex process regulated by coordination of various signaling pathways. In this study, we investigated the role of sox18 in heart development by modulating Wnt/β-Catenin signaling pathways. Our spatiotemporal expression analysis revealed that sox18 is mainly expressed in the heart, branchial arch, pharyngeal arch, spinal cord, and intersegmental vessels at the tailbud stage of Xenopus tropicalis embryo. Overexpression of sox18 in the X. tropicalis embryos causes heart edema, while loss-of-function of sox18 can change the signal of developmental heart marker gata4 at different stages, suggesting that sox18 plays an essential role in the development of the heart. Knockdown of SOX18 in human umbilical vein endothelial cells suggests a link between Sox18 and β-CATENIN, a key regulator of the Wnt signaling pathway. Sox18 negatively regulates islet1 and tbx3, the downstream factors of Wnt/β-Catenin signaling, during the linear heart tube formation and the heart looping stage. Taken together, our findings highlight the crucial role of Sox18 in the development of the heart via inhibiting Wnt/β-Catenin signaling.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Heart development
- Sox18
- Transcriptional factor
- Wnt signaling pathway
- Xenopus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Liang, Jianxin
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Ul Hassan, Imtia ...
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Yee Cheung, Man
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Feng, Lei
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Lin, Yi jyun
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Long, Qi
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Wang, Chengdong
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Ding, Yuyue
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Wang, Ziqing
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Zhang, Yuan
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Li, Yulong
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Guo, Donghao
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Guo, Xiaofang
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Chi Bun Wong, Th ...
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Kaleem Samma, Mu ...
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Rong, Zixin
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Qi, Xufeng
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Cai, Dongqing
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Ngai, Sai Ming
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Zhao, Hui
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