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Sökning: id:"swepub:oai:DiVA.org:kth-346380" > FFR-Guided Complete...

FFR-Guided Complete or Culprit-Only PCI in Patients with Myocardial Infarction

Böhm, Felix (författare)
The Department of Cardiology, Karolinska Institute, Danderyd Hospital, Danderyd, Sweden,Karolinska Inst, Sweden; Danderyd Hosp, Sweden
Mogensen, Brynjölfur (författare)
The Department of Cardiology, Karolinska Institutet, Danderyd Hospital,Karolinska Inst, Sweden; Danderyd Hosp, Sweden
Engstrøm, Thomas (författare)
The Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Denmark
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Stankovic, Goran (författare)
The University Clinical Center of Serbia, The Faculty of Medicine, University of Belgrade, Belgrade, Serbia,Univ Belgrade, Serbia
Srdanovic, Ilija (författare)
The Faculty of Medicine, University of Novi Sad, Institute of Cardiovascular Diseases Vojvodina, Sremska Kamenica, Serbia,Univ Novi Sad, Serbia
Lønborg, Jacob (författare)
The Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Denmark
Zwackman, Sammy (författare)
Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
Hamid, Mehmet (författare)
The Department of Cardiology, Mälarsjukhuset, Eskilstuna, Sweden
Kellerth, Thomas (författare)
The Department of Cardiology, Central Hospital, Karlstad, Sweden,Cent Hosp Karlstad, Sweden
Lauermann, Jörg (författare)
The Department of Cardiology, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden
Kajander, Olli A. (författare)
The Heart Hospital, Tampere University Hospital, The Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland,Tampere Univ, Finland; Tampere Univ, Finland
Andersson, Jonas (författare)
Umeå universitet,Kardiologi,Umea Univ Hosp, Sweden
Linder, Rikard (författare)
Karolinska Institutet
Angerås, Oskar, 1976 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
Renlund, Henrik (författare)
The Department of Medical Sciences, Uppsala University, Uppsala, Sweden,Uppsala Univ, Sweden
Ērglis, Andrejs (författare)
The Latvian Center of Cardiology, Pauls Stradins Clinical University Hospital, University of Latvia, Riga, Latvia,Univ Latvia, Latvia
Menon, Madhav (författare)
The Cardiology Department, Waikato Hospital, Hamilton, New Zealand,Waikato Hosp, New Zealand
Schultz, Carl (författare)
The Medical School, University of Western Australia, The Department of Cardiology, Royal Perth Hospital, Perth, WA, Australia,Univ Western Australia, Australia; Royal Perth Hosp, Australia
Laine, Mika (författare)
The Heart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland,Helsinki Univ Cent Hosp, Finland
Held, Claes (författare)
The Department of Medical Sciences, Uppsala University, Uppsala, Sweden,Uppsala Univ, Sweden; Uppsala Univ, Sweden
Rück, Andreas (författare)
Karolinska Institutet
Östlund, Ollie (författare)
The Department of Medical Sciences, Uppsala University, Uppsala, Sweden,Uppsala Univ, Sweden
James, Stefan (författare)
The Department of Medical Sciences, Uppsala University, Uppsala, Sweden,Uppsala Univ, Sweden; Uppsala Univ, Sweden
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 (creator_code:org_t)
Massachusetts Medical Society, 2024
2024
Engelska.
Ingår i: New England Journal of Medicine. - : Massachusetts Medical Society. - 0028-4793 .- 1533-4406. ; 390:16, s. 1481-1492
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: The benefit of fractional flow reserve (FFR)-guided complete revascularization in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease remains unclear. METHODS: In this multinational, registry-based, randomized trial, we assigned patients with STEMI or very-high-risk non-STEMI (NSTEMI) and multivessel disease who were undergoing primary percutaneous coronary intervention (PCI) of the culprit lesion to receive either FFR-guided complete revascularization of nonculprit lesions or no further revascularization. The primary outcome was a composite of death from any cause, myocardial infarction, or unplanned revascularization. The two key secondary outcomes were a composite of death from any cause or myocardial infarction and unplanned revascularization. RESULTS: A total of 1542 patients underwent randomization, with 764 assigned to receive FFR-guided complete revascularization and 778 assigned to receive culprit-lesion-only PCI. At a median follow-up of 4.8 years (interquartile range, 4.3 to 5.2), a primary-outcome event had occurred in 145 patients (19.0%) in the complete-revascularization group and in 159 patients (20.4%) in the culprit-lesion-only group (hazard ratio, 0.93; 95% confidence interval [CI], 0.74 to 1.17; P = 0.53). With respect to the secondary outcomes, no apparent between-group differences were observed in the composite of death from any cause or myocardial infarction (hazard ratio, 1.12; 95% CI, 0.87 to 1.44) or unplanned revascularization (hazard ratio, 0.76; 95% CI, 0.56 to 1.04). There were no apparent between-group differences in safety outcomes. CONCLUSIONS: Among patients with STEMI or very-high-risk NSTEMI and multivessel coronary artery disease, FFR-guided complete revascularization was not shown to result in a lower risk of a composite of death from any cause, myocardial infarction, or unplanned revascularization than culprit-lesion-only PCI at 4.8 years. (Funded by the Swedish Research Council and others; FULL REVASC ClinicalTrials.gov number, NCT02862119.).

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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