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Evaluating the impa...
Evaluating the impact of a rigid and a deformable registration method of pre-treatment images for hypoxia-based dose painting
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- Lazzeroni, M. (författare)
- Physics Department, Stockholm University, Sweden; Oncology-Pathology Department, Karolinska Institute, Stockholm, Sweden
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- Ureba, A. (författare)
- Physics Department, Stockholm University, Sweden; Oncology-Pathology Department, Karolinska Institute, Stockholm, Sweden
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Rosenberg, V. (författare)
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- Schäfer, H. (författare)
- Department of Radiation Oncology, University Medical Center, Medical Faculty University of Freiburg, German Cancer Consortium (DKTK) Partner Site Freiburg, Germany
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- Rühle, A. (författare)
- Department of Radiation Oncology, University Medical Center, Medical Faculty University of Freiburg, German Cancer Consortium (DKTK) Partner Site Freiburg, Germany; University of Leipzig Medical Center, Department of Radiation Oncology, Leipzig, Germany
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- Baltas, D. (författare)
- Department of Radiation Oncology, University Medical Center, Medical Faculty University of Freiburg, German Cancer Consortium (DKTK) Partner Site Freiburg, Germany
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- Toma-Dasu, I. (författare)
- Physics Department, Stockholm University, Sweden; Oncology-Pathology Department, Karolinska Institute, Stockholm, Sweden
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- Grosu, A. L. (författare)
- Department of Radiation Oncology, University Medical Center, Medical Faculty University of Freiburg, German Cancer Consortium (DKTK) Partner Site Freiburg, Germany
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(creator_code:org_t)
- Elsevier BV, 2024
- 2024
- Engelska.
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Ingår i: Physica medica (Testo stampato). - : Elsevier BV. - 1120-1797 .- 1724-191X. ; 122
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose: To assess the impact of rigid and deformable image registration methods (RIR, DIR) on the outcome of a hypoxia-based dose painting strategy. Materials and methods: Thirty head and neck cancer patients were imaged with [18F]FMISO-PET/CT before radiotherapy. [18F]FMISO-PET/CT images were registered to the planning-CT by RIR or DIR. The [18F]FMISO uptake was converted into oxygen partial pressure (pO2) maps. Hypoxic Target Volumes were contoured on pO2 maps for the deformed (HTVdef) and non-deformed (HTV) cases. A dose escalation strategy by contours, aiming at 95 % tumour control probability (TCP), was applied. HTVs were characterised based on geometry-related metrics, the underlying pO2 distribution, and the dose boost level. A dosimetric and radiobiological evaluation of selected treatment plans made considering RIR and DIR was performed. Moreover, the TCP of the RIR dose distribution was evaluated when considering the deformed [18F]FMISO-PET image as an indicator of the actual target radiosensitivity to determine the potential impact of an unalignment. Results: Statistically significant differences were found between HTV and HTVdef for volume-based metrics and underlying pO2 distribution. Eight out of nine treatment plans for HTV and HTVdef showed differences on the level 10 %/3 mm on a gamma analysis. The TCP difference, however, between RIR and the case when the RIR dose distribution was used with the deformed radiosensitivity map was below 2 pp. Conclusions: Although the choice of the CTplan-to-PET registration method pre-treatment impacts the HTV localisation and morphology and the corresponding dose distribution, it negligibly affects the TCP in the proposed dose escalation strategy by contours.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Dose painting
- Hypoxia
- Image registration
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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