A Suzuki-type cross-coupling reaction of arylacetylene halides with arylboronic acids

• A PdCl(2)-catalyzed direct alkynylation of arylboronic acids to give diarylacetylenes is described. The optimal conditions using PdCl(2) as catalyst, MeOH-PhMe-H(2)O as solvent and K(2)CO(3) as base effectively suppressed the formation of homo-coupling product and afforded moderate to good yield of the desired unsymmetrical coupling product. This reaction represents a Suzuki-type sp(2)(C-B)-sp(C-X) cross-coupling.

Ämnesord

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Nyckelord

Suzuki cross-coupling

diarylacetylene

palladium chloride

alkynylation

Chemistry

Kemi

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