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Acute normobaric hy...
Acute normobaric hyperoxia transiently attenuates plasma erythropoietin concentration in healthy males : evidence against the 'normobaric oxygen paradox' theory
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Keramidas, Michail E. (författare)
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Kounalakis, S. N. (författare)
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Debevec, T. (författare)
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- Norman, B. (författare)
- Karolinska Institutet
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- Gustafsson, T. (författare)
- Karolinska Institutet
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- Eiken, Ola (författare)
- KTH,Omgivningsfysiologi
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Mekjavic, I. B. (författare)
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(creator_code:org_t)
- 2011-03-18
- 2011
- Engelska.
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Ingår i: Acta Physiologica. - : Wiley-Blackwell. - 1748-1708 .- 1748-1716. ; 202:1, s. 91-98
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- Aim: The purpose of the present study was to evaluate the 'normobaric oxygen paradox' theory by investigating the effect of a 2-h normobaric O(2) exposure on the concentration of plasma erythropoietin (EPO). Methods: Ten healthy males were studied twice in a single-blinded counterbalanced crossover study protocol. On one occasion they breathed air (NOR) and on the other 100% normobaric O(2) (HYPER). Blood samples were collected Pre, Mid and Post exposure; and thereafter, 3, 5, 8, 24, 32, 48, 72 and 96 h, and 1 and 2 weeks after the exposure to determine EPO concentration. Results: The concentration of plasma erythropoietin increased markedly 8 and 32 h after the NOR exposure (approx. 58% and approx. 52%, respectively, P < 0.05) as a consequence of its natural diurnal variation. Conversely, the O(2) breathing was followed by approx. 36% decrement of EPO 3 h after the exposure (P < 0.05). Moreover, EPO concentration was significantly lower in HYPER than in the NOR condition 3, 5 and 8 h after the breathing intervention (P < 0.05). Conclusion: In contrast to the 'normobaric oxygen paradox' theory, the present results indicate that a short period of normobaric O(2) breathing does not increase the EPO concentration in aerobically fit healthy males. Increased O(2) tension suppresses the EPO concentration 3 and 5 h after the exposure; thereafter EPO seems to change in a manner consistent with natural diurnal variation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- diurnal variation
- erythropoiesis
- hyperoxaemia
- individual variability
- oxygen therapy
- Physiology
- Fysiologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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