A versatile functional-anatomic image fusion method for volume data sets

• We describe and validate a volumetric three-dimensional registration method, and compare it to our previously validated two-dimensional/three-dimensional method. {CT/MRI} and {SPECT} data from 14 patients were interactively fused using a polynomial warping technique. Registration accuracy was confirmed visually and by a nonsignificant F value from multivariate analysis of the transformed landmarks, a significant difference of the squared sum of intensity differences between the transformed/untransformed and the reference volume both at the 0.05 (p {\textgreater} 0.05) confidence level and an average 31\% improvement of the correlation coefficient and cross correlation. For the two-dimensional/three-dimensional method, {ROI} center-to-center distance ranged from 1.42 to 11.32 mm (for liver) with an average of 6.13 mm +/- 3.09 mm. The average {ROI} overlap was 92.51\% with a 95\% confidence interval of 90.20-96.88\%. The new method is superior because it operates on the true three-dimensional volume. Both methods give good registration results, take 10 to 30 min, and require anatomic knowledge.

Nyckelord

Humans

Imaging

{Three-Dimensional}

Magnetic Resonance Imaging

Neoplasms

Radiography

Abdominal

Radiography

Thoracic

Tomography

{Emission-Computed}

{Single-Photon}

Tomography

{X-Ray} Computed

SRA - ICT

SRA - Informations- och kommunikationsteknik

Publikations- och innehållstyp

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