Redox-Responsive and Calcium-Dependent Switching of Glycosyldisulfide Interactions with Concanavalin A

• Glycosyldisulfides can interact efficiently with carbohydrate-binding entities. This has been shown for a range of thiosaccharide dimers when tested for their effects against the lectin Concanavalin A using a modified quartz crystal microbalance-technique. Contrary to the thiosaccharide monomers, showing no significant binding up to 10 mM, several of the dimers showed IC50-values in the low millimolar range. Three of the glycosyldisulfides tested also displayed very high positive apparent cooperativity effects that were found to be both calcium-dependent and redox-responsive.

Ämnesord

NATURVETENSKAP  -- Kemi -- Organisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Organic Chemistry (hsv//eng)

Nyckelord

dynamic chemistry

glycochemistry

molecular recognition

lectins

thiosaccharides

quartz crystal microbalance

Organic chemistry

Organisk kemi

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)