Diastereoselective Aldol Additions to α-Amino-β-Silyloxy Aldehydes. Divergent Synthesis of Aminodiols

• A divergent protocol for substrate-controlled diastereoselective synthesis of aminodiols has been developed using nucleophilic Mukaiyama aldol additions to alpha-amino-beta-silyloxy aldehydes. The merged stereochemical impact on the diastereoselectivity of the polar alpha- and beta-substituents is highlighted.

Ämnesord

NATURVETENSKAP  -- Kemi -- Organisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Organic Chemistry (hsv//eng)

Nyckelord

MERGED STEREOCHEMICAL IMPACT

1

3-ASYMMETRIC INDUCTION

ALKOXY ALDEHYDES

LEWIS-ACIDS

ALLYLTRIMETHYLSILANE

Organic chemistry

Organisk kemi

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)