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Allosteric changes ...
Allosteric changes of the NMDA receptor trap diffusible dopamine 1 receptors in spines
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- Scott, Lena (författare)
- Karolinska Institutet
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- Zelenin, Sergey (författare)
- Karolinska Institutet
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- Malmersjö, Seth (författare)
- Karolinska Institutet
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- Kowalewski, Jacob M (författare)
- KTH,Cellens fysik
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- Zettergren Markus, Eivor (författare)
- Department of Woman and Child Health, Karolinska Institutet
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- Nairn, Angus C (författare)
- Department of Psychiatry, Yale University School of Medicine, New Haven, CT
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- Greengard, Paul (författare)
- Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University
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- Brismar, Hjalmar (författare)
- Karolinska Institutet,KTH,Cellens fysik
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- Aperia, Anita (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2006-01-09
- 2006
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 103:3, s. 762-767
- Relaterad länk:
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http://www.pnas.org/...
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http://www.pnas.org/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The dopaminergic and glutamatergic systems interact to initiate and organize normal behavior, a communication that may be perturbed in many neuropsychiatric diseases, including schizophrenia. We show here that NMDA, by allosterically modifying NMDA receptors, can act as a scaffold to recruit laterally diffusing dopamine D1 receptors (D1R) to neuronal spines. Using organotypic culture from rat striatum transfected with D1R fused to a fluorescent protein, we show that the majority of dendritic D1R are in lateral diffusion and that their mobility is confined by interaction with NMDA receptors. Exposure to NMDA reduces the diffusion coefficient for D1R and causes an increase in the number of D1R-positive spines. Unexpectedly, the action of NMDA in potentiating D1R recruitment was independent of calcium flow via the NMDA receptor channel. Thus, a highly energy-efficient, diffusion-trap mechanism can account for intraneuronal interaction between the glutamatergic and dopaminergic systems and for regulation of the number of D1R-positive spines. This diffusion trap system represents a molecular mechanism for brain plasticity and offers a promising target for development of antipsychotic therapy
Ämnesord
- NATURVETENSKAP -- Fysik -- Den kondenserade materiens fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Condensed Matter Physics (hsv//eng)
Nyckelord
- Fluorescence recovery after photo-bleaching; Lateral diffusion; Organotypic cultures; Receptor movement
- Biological physics
- Biologisk fysik
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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