Ill-Conditioning : A Property of Bio Networks

• Analysis of large gene expression datasetsshows that they all share the same feature; the variance isconcentrated to significantly fewer orthogonal directions thanthe applied perturbations span. Given that all perturbationsare of same magnitude, this shows that the underlyingnetworks are ill-conditioned. We establish ill-conditioning as ageneric property of biochemical networks, resulting from thefact that all networks need to provide both signal amplificationand disturbance attenuation. One consequence of illconditioningis the commonly observed co-expression of genes.

Ämnesord

TEKNIK OCH TEKNOLOGIER  -- Elektroteknik och elektronik -- Reglerteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Electrical Engineering, Electronic Engineering, Information Engineering -- Control Engineering (hsv//eng)

NATURVETENSKAP  -- Biologi -- Bioinformatik och systembiologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)

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