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Ill-Conditioning :
Ill-Conditioning : A Property of Bio Networks
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- Nordling, Torbjörn E. M. (författare)
- KTH,Reglerteknik
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- Jacobsen, Elling W., 1963- (författare)
- KTH,Reglerteknik
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(creator_code:org_t)
- 2008
- 2008
- Engelska.
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Ingår i: Proceedings of 2nd q-Bio Conference on Cellular Information Processing, 2008.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Analysis of large gene expression datasetsshows that they all share the same feature; the variance isconcentrated to significantly fewer orthogonal directions thanthe applied perturbations span. Given that all perturbationsare of same magnitude, this shows that the underlyingnetworks are ill-conditioned. We establish ill-conditioning as ageneric property of biochemical networks, resulting from thefact that all networks need to provide both signal amplificationand disturbance attenuation. One consequence of illconditioningis the commonly observed co-expression of genes.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Elektroteknik och elektronik -- Reglerteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Electrical Engineering, Electronic Engineering, Information Engineering -- Control Engineering (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- kon (ämneskategori)