Surface Functionalization of Degradable Polymers by Covalent Grafting

• With a new non-destructive and solvent-free photografting technique, N-vinylpyrrolidone was covalently grafted onto the surfaces of degradable polymers; poly(L-lactide), poly(L-caprolactone), poly(lactide-co-glycolide),. and poly(trimethylene carbonate). The modified surfaces were characterized by XPS, ATR-FTIR, SEM.. and cell growth tests. The wettability was markedly improved, as static contact angles changed from about 80 degrees for the pristine substrates to around 30 degrees after 30 min of grafting. Well-defined surface topographies, such as micro-patterns, are preserved in the process since the graft layers are thin. The biological response, measured as cytotoxicity, showed that the modified films provide good substrates, comparable with optimized cell culture plastics, for the adhesion and proliferation of normal human keratinocytes and skin fibroblasts.

Ämnesord

NATURVETENSKAP  -- Kemi -- Polymerkemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Polymer Chemistry (hsv//eng)

Nyckelord

Covalent; Degradable; N-vinyl pyrrolidone; Solvent free; Surface modification; Vapor-phase grafting; Adhesion; Cell culture; Degradation; Substrates; Surface treatment; 1 vinyl 2 pyrrolidinone; carbonic acid derivative; polycaprolactone; polyglactin; polylactide; polymer; polytrimethylene carbonate; solvent; unclassified drug; article; biocompatibility; cell adhesion; cell assay; cell culture; cell growth; cell proliferation; controlled study; covalent bond; cytotoxicity; drug degradation; drug structure; film; human; human cell; infrared spectroscopy; keratinocyte; light; normal human; priority journal; scanning electron microscopy; skin fibroblast; surface property; time; Biocompatible Materials; Biodegradation

Environmental; Cell Adhesion; Cell Proliferation; Cells

Cultured; Dioxanes; Fibroblasts; Humans; Photochemistry; Polyesters; Polyglactin 910; Polymers; Pyrrolidinones; Skin; Surface Properties; Ultraviolet Rays

Polymer chemistry

Polymerkemi

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