Domino Carbopalladation-Carbonylation : Investigation of Substrate Scope

• This work gives an in depth account of our domino carbopalladation-carbonylation method for substrates possessing beta-hydrogens. The scope of the method is examined for allylic amines containing trisubstituted olefins and we detail our attempts toward the diastereospecific synthesis of contiguous quaternary centers using this technology. The results give key insights into the relative rates of the competing reactions of the alkyl palladium intermediates, which is crucial for the understanding and development of new domino processes.

Ämnesord

NATURVETENSKAP  -- Kemi -- Organisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Organic Chemistry (hsv//eng)

Nyckelord

carbonylation

domino reactions

Heck reaction

oxindoles

quaternary stereocenters

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