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The neuropeptide Y ...
The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice
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- Karlsson, Rose-Marie (författare)
- National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
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- Choe, Jessica S. (författare)
- National Institute of Mental Health, NIH, Bethesda, MD, USA
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- Cameron, Heather A (författare)
- National Institute of Mental Health, NIH, Bethesda, MD, USA
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- Thorsell, Annika (författare)
- National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
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- Crawley, Jacqueline N (författare)
- National Institute of Mental Health, NIH, Bethesda, MD, USA
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- Holmes, Andrew (författare)
- National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
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- Heilig, Markus (författare)
- National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
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(creator_code:org_t)
- 2007-09-22
- 2008
- Engelska.
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Ingår i: Psychopharmacology. - : Springer. - 0033-3158 .- 1432-2072. ; 195:4, s. 547-557
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- RATIONALE: Neuropeptide Y (NPY) is implicated in the pathophysiology of affective illness. Multiple receptor subtypes (Y1R, Y2R, and Y5R) have been suggested to contribute to NPY's effects on rodent anxiety and depression-related behaviors.OBJECTIVES: To further elucidate the role of Y1R in (1) NPY's anxiolytic-like effects and (2) fluoxetine's antidepressant-like and neurogenesis-inducing effects.METHODS: Mice lacking Y1R were assessed for spontaneous anxiety-like behavior (open field, elevated plus-maze, and light/dark exploration test) and Pavlovian fear conditioning, and for the anxiolytic-like effects of intracerebroventricularly (icv)-administrated NPY (elevated plus-maze). Next, Y1R -/- were assessed for the antidepressant-like effects of acute fluoxetine in the forced swim test and chronic fluoxetine in the novelty-induced hypophagia test, as well as for chronic fluoxetine-induced hippocampal neurogenesis.RESULTS: Y1R -/- exhibited largely normal baseline behavior as compared to +/+ littermate controls. Intraventricular administration of NPY in Y1R -/- mice failed to produce the normal anxiolytic-like effect in the elevated plus-maze test seen in +/+ mice. Y1R mutant mice showed higher immobility in the forced swim test and longer latencies in the novelty-induced hypophagia test. In addition, Y1R -/- mice responded normally to the acute and chronic effects of fluoxetine treatment in the forced swim test and the novelty-induced hypophagia test, respectively, as well as increased neuronal precursor cell proliferation in the hippocampus.CONCLUSIONS: These data demonstrate that Y1R is necessary for the anxiolytic-like effects of icv NPY, but not for the antidepressant-like or neurogenesis-inducing effects of fluoxetine. The present study supports targeting Y1R as a novel therapeutic target for anxiety disorders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Neuropeptide Y
- Y1
- Receptor
- Knockout
- Mouse
- Fear
- Anxiety
- Depression
- Neurogenesis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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