Search: id:"swepub:oai:DiVA.org:liu-104670" >
Thalamic Activation...
Thalamic Activation in the Kleine-Levin Syndrome
-
- Engström, Maria, 1958- (author)
- Linköpings universitet,Avdelningen för radiologiska vetenskaper,Hälsouniversitetet,Centrum för medicinsk bildvetenskap och visualisering, CMIV
-
- Karlsson, Thomas (author)
- Linköpings universitet,Handikappvetenskap,Filosofiska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV
-
- Landtblom, Anne-Marie (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för neurovetenskap,Hälsouniversitetet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Neurologiska kliniken,Medicinska specialistkliniken,Department of Clinical and Experimental Medicine (IKE), Division of Neurology, Linköping University, UHL, LiM, Linköping, Sweden
-
(creator_code:org_t)
- 2014-02-01
- 2014
- English.
-
In: Sleep. - United States : Associated Professional Sleep Societies, Llc. - 0161-8105 .- 1550-9109. ; 37:2, s. 379-386
- Related links:
-
https://academic.oup...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.5...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- STUDY OBJECTIVES:The objective of this study was to investigate if combined measures of activation in the thalamus and working memory capacity could guide the diagnosis of Kleine-Levin Syndrome (KLS). A second objective was to obtain more insight into the neurobiological causes of KLS.DESIGN:Matched group and consecutive recruitment.SETTING:University hospital neurology department and imaging center.PATIENTS OR PARTICIPANTS:Eighteen patients with KLS diagnosed according to the International Classification of Sleep Disorders and 26 healthy controls were included.INTERVENTIONS:N/A.MEASUREMENTS AND RESULTS:Working memory capacity was assessed by the listening span task. A version of this task (reading span) was presented to the participants during functional magnetic resonance imaging (fMRI). Activation in the thalamus was measured in a region of interest analysis. A combination of the working memory capacity and the thalamic activation measures resulted in 80% prediction accuracy, 81% sensitivity, and 78% specificity regarding the ability to separate KLS patients from healthy controls. The controls had an inverse relation between working memory capacity and thalamic activation; higher performing participants had lower thalamic activation (r = -0.41). KLS patients showed the opposite relationship; higher performing participants had a tendency to higher thalamic activation (r = -0.35).CONCLUSIONS:This study shows that functional neuroimaging of the thalamus combined with neuropsychological assessment of working memory function provides a means to guide diagnosis of Kleine-Levin Syndrome. Results in this study also indicate that imaging of brain function and evaluation of cognitive capacity can give insights into the neurobiological mechanisms of Kleine-Levin Syndrome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Functional magnetic resonance imaging (fMRI)
- hypersomnia
- narcolepsy
- thalamus
- working memory
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Sleep
(Search for host publication in LIBRIS)
To the university's database