Outcome and Treatment of Elderly Patients with ANCA-Associated Vasculitis

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Outcome and Treatment of Elderly Patients with ANCA-Associated Vasculitis

Weiner, Maria (författare): Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US

Goh, Su Mein (författare): University College London Centre for Nephrology, Royal Free Hospital, London, United Kingdom

Mohammad, Aladdin (författare): Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden; Vasculitis and Lupus Clinic, Addenbrooke's Hospital, Cambridge, United Kingdom

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Hruskova, Zdenka (författare): Charles Univ Prague, Fac Med 1, Dept Nephrol, Prague, Czech Republic, Gen Univ Hosp, Prague, Czech Republic

Tanna, Anisha (författare): Department of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic

Bruchfeld, Annette (författare): Karolinska Institutet,Univ London Imperial Coll Sci Technol & Med, Dept Med, London, England, Karolinska Univ Hosp, Dept Renal Med, Stockholm, Sweden

Selga, Daina (författare): Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Renal Medicine, Karolinska University Hospital, and Department of Clinical Sciences, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden; and.

Chocova, Zdenka (författare): Department of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republi

Westman, Kerstin (författare): Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö, Sweden

Eriksson, Per (författare): Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Reumatologiska kliniken i Östergötland,Medicinska fakulteten

Pusey, Charles D (författare): Department of Medicine, Imperial College London, London, United Kingdom;

Tesar, Vladimir (författare): Department of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic;

Salama, Alan D (författare): University College London Centre for Nephrology, Royal Free Hospital, London, United Kingdom;

Segelmark, Mårten (författare): Lund University,Lunds universitet,Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine

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American Society of Nephrology, 2015
2015
Engelska.
Ingår i: Clinical journal of the American Society of Nephrology : CJASN. - : American Society of Nephrology. - 1555-905X. ; 10:7, s. 1128-1135

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BACKGROUND AND OBJECTIVES: ANCA-associated vasculitis is commonly found in elderly patients, but there are few data concerning outcome and treatment in the highest age groups.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Consecutive patients (N=151) presenting between 1997 and 2009 were retrospectively included from local registries in six centers in Sweden, the United Kingdom, and the Czech Republic if diagnosed with microscopic polyangiitis or granulomatosis with polyangiitis at age ≥75 years during the study period. Patients were followed until 2 years from diagnosis or death. Data on survival and renal function were analyzed with respect to age, sex, ANCA specificity, renal function, C-reactive protein, comorbidities, and Birmingham Vasculitis Activity Score at diagnosis as well as treatment during the first month.RESULTS: Median follow-up was 730 days (interquartile range, 244-730). Overall 1-year survival was 71.5% and 2-year survival was 64.6%. Older age, higher creatinine, and lower Birmingham Vasculitis Activity Score were associated with higher mortality in multivariable analysis. Patients who were not treated with standard immunosuppressive therapy had significantly worse survival. Renal survival was 74.8% at 1 year. No new cases of ESRD occurred during the second year. High creatinine at diagnosis was the only significant predictor of renal survival in multivariable analysis.CONCLUSIONS: ANCA-associated vasculitis is a disease with substantial mortality and morbidity among elderly patients. This study showed a better prognosis for those who received immunosuppressive treatment and those who were diagnosed before having developed advanced renal insufficiency.

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Clinical journal of the American Society of Nephrology : CJASN (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Weiner, Maria; Goh, Su Mein; Mohammad, Aladdi ...; Hruskova, Zdenka; Tanna, Anisha; Bruchfeld, Annet ...; visa fler...; Selga, Daina; Chocova, Zdenka; Westman, Kerstin; Eriksson, Per; Pusey, Charles D; Tesar, Vladimir; Salama, Alan D; Segelmark, Mårte ...; visa färre...

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Artiklar i publikationen: Clinical journal ...

Av lärosätet: Linköpings universitet; Lunds universitet; Karolinska Institutet

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Outcome and Treatment of Elderly Patients with ANCA-Associated Vasculitis

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