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Use of tramadol in ...
Use of tramadol in early pregnancy and congenital malformation risk
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- Källén, Bengt (författare)
- Lund University,Lunds universitet,Tornbladinstitutet,Forskargrupper vid Lunds universitet,Tornblad Institute,Lund University Research Groups,Lund University, Sweden
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- Reis, Margareta (författare)
- Lund University,Lunds universitet,Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Skåne University Hospital, Sweden,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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(creator_code:org_t)
- PERGAMON-ELSEVIER SCIENCE LTD, 2015
- 2015
- Engelska.
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Ingår i: Reproductive Toxicology. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0890-6238 .- 1873-1708. ; 58, s. 246-251
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Abstract
Ämnesord
Stäng
- Only few studies exist regarding the risk of a teratogenic effect of tramadol when used in early pregnancy. Using the Swedish Medical Birth Register, women (deliveries in 1997-2013) who had reported the use of tramadol in early pregnancy were identified. Maternal characteristics and concomitant drug use were analyzed. Among 1,682,846 women (1,797,678 infants), 1751 (1776 infants) had used tramadol, 96 of the infants had a congenital malformation and 70 of them were relatively severe. The adjusted odds ratio for a relatively severe malformation was 1.33 (95% CI 1.05-1.70). The odds ratios for cardiovascular defects (1.56, 95% CI 1.04-2.29) and for pes equinovarus (3.63, 95% CI 1.61-6.89) were significantly increased. The study suggests a teratogenic effect of tramadol but the risk increase is moderate. (C) 2015 Elsevier Inc. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Congenital malformations; Opioids; Pes equinovarus; Cardiovascular defects; Tramadol
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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