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Resveratrol analogu...
Resveratrol analogue 4,4 -dihydroxy-trans-stilbene potently inhibits cancer invasion and metastasis
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- Savio, Monica (författare)
- University of Pavia, Italy
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- Ferraro, Daniela (författare)
- University of Pavia, Italy
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- Maccario, Cristina (författare)
- University of Pavia, Italy
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visa fler...
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- Vaccarone, Rita (författare)
- University of Pavia, Italy
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- Jensen, Lasse (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Klinisk farmakologi,Karolinska Institute, Sweden
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- Corana, Federica (författare)
- University of Pavia, Italy
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- Mannucci, Barbara (författare)
- University of Pavia, Italy
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- Bianchi, Livia (författare)
- University of Pavia, Italy
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- Cao, Yihai (författare)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Anna Stivala, Lucia (författare)
- University of Pavia, Italy
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(creator_code:org_t)
- 2016-02-01
- 2016
- Engelska.
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Ingår i: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 6:19973
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- We investigated the preventive effects of resveratrol analogue 4,4-dihydroxy-trans-stilbene (DHS) on cancer invasion and metastasis. Two different in vivo approaches of mouse and zebrafish lung cancer invasion models were employed in our study. The in vitro results showed that DHS displays potent inhibition on anchorage-dependent or -independent cell growth of LLC cells, leading to impairment of the cell cycle progression with reduction of cell numbers arresting at the G1 phase, an evident accumulation of pre-G1 events correlated with apoptotic behaviour. In addition, DHS induces a marked inhibition of LLC cell migration and matrigel invasion. In a murine lung cancer model, tumour volume, cell proliferation, and tumour angiogenesis were significantly inhibited by DHS. Importantly, liver metastatic lesions were significantly reduced in DHS-treated mice. Similarly, DHS significantly inhibits lung cancer cell dissemination, invasion and metastasis in a zebrafish tumour model. These findings demonstrate that DHS could potentially be developed as a novel therapeutic agent for treatment of cancer and metastasis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Savio, Monica
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Ferraro, Daniela
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Maccario, Cristi ...
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Vaccarone, Rita
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Jensen, Lasse
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Corana, Federica
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visa fler...
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Mannucci, Barbar ...
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Bianchi, Livia
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Cao, Yihai
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Anna Stivala, Lu ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Scientific Repor ...
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet