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Genome-wide Associa...
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture
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- Stuart, Philip E. (författare)
- University of Michigan, MI 48109 USA
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- Nair, Rajan P. (författare)
- University of Michigan, MI 48109 USA
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- Tsoi, Lam C. (författare)
- University of Michigan, MI 48109 USA; University of Michigan, MI 48109 USA; University of Michigan, MI 48109 USA
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- Tejasvi, Trilokraj (författare)
- University of Michigan, MI 48109 USA; Ann Arbor Vet Affairs Hospital, MI 48105 USA
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- Das, Sayantan (författare)
- University of Michigan, MI 48109 USA
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- Min Kang, Hyun (författare)
- University of Michigan, MI 48109 USA
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- Ellinghaus, Eva (författare)
- University of Kiel, Germany
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- Chandran, Vinod (författare)
- University of Toronto, Canada; University of Toronto, Canada
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- Callis-Duffin, Kristina (författare)
- University of Utah, UT 84132 USA
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- Ike, Robert (författare)
- University of Michigan, MI 48109 USA
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- Li, Yanming (författare)
- University of Michigan, MI 48109 USA
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- Wen, Xiaoquan (författare)
- University of Michigan, MI 48109 USA
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- Enerbäck, Charlotta (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland
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- Gudjonsson, Johann E. (författare)
- University of Michigan, MI 48109 USA
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- Koks, Sulev (författare)
- University of Tartu, Estonia; University of Tartu, Estonia; Estonian University of Life Science, Estonia
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- Kingo, Kuelli (författare)
- University of Tartu, Estonia
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- Esko, Tonu (författare)
- University of Tartu, Estonia
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- Mrowietz, Ulrich (författare)
- University of Medical Centre Schleswig Holstein, Germany
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- Reis, Andre (författare)
- University of Erlangen Nurnberg, Germany
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- Erich Wichmann, H. (författare)
- German Research Centre Environm Heatlh, Germany; University of Munich, Germany; Technical University of Munich, Germany
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- Gieger, Christian (författare)
- German Research Centre Environm Heatlh, Germany; German Research Centre Environm Heatlh, Germany
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- Hoffmann, Per (författare)
- University of Bonn, Germany; University of Bonn, Germany
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- Noethen, Markus M. (författare)
- University of Bonn, Germany; University of Bonn, Germany
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- Winkelmann, Juliane (författare)
- Technical University of Munich, Germany; German Research Centre Environm Heatlh, Germany
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- Kunz, Manfred (författare)
- University of Leipzig, Germany
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- Moreta, Elvia G. (författare)
- St Paul Rheumatol, MN 55121 USA
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- Mease, Philip J. (författare)
- Seattle Rheumatol Associates, WA 98122 USA
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- Ritchlin, Christopher T. (författare)
- University of Rochester, NY 14623 USA
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- Bowcock, Anne M. (författare)
- University of London Imperial Coll Science Technology and Med, England
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- Krueger, Gerald G. (författare)
- University of Utah, UT 84132 USA
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- Lim, Henry W. (författare)
- Henry Ford Hospital, MI 48202 USA
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- Weidinger, Stephan (författare)
- University of Medical Centre Schleswig Holstein, Germany
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- Weichenthal, Michael (författare)
- University of Medical Centre Schleswig Holstein, Germany
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- Voorhees, John J. (författare)
- University of Michigan, MI 48109 USA
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- Rahman, Proton (författare)
- Mem University, Canada
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- Gregersen, Peter K. (författare)
- North Shore Long Isl Jewish Health Syst, NY 11030 USA
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- Franke, Andre (författare)
- University of Kiel, Germany
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- Gladman, Dafna D. (författare)
- University of Toronto, Canada; University of Toronto, Canada
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- Abecasis, Goncalo R. (författare)
- University of Michigan, MI 48109 USA
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- Elder, James T. (författare)
- University of Michigan, MI 48109 USA; Ann Arbor Vet Affairs Hospital, MI 48105 USA
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(creator_code:org_t)
- CELL PRESS, 2015
- 2015
- Engelska.
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Ingår i: American Journal of Human Genetics. - : CELL PRESS. - 0002-9297 .- 1537-6605. ; 97:6, s. 816-836
- Relaterad länk:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Psoriasis vulgaris (PsV) is a common inflammatory and hyperproliferative skin disease. Up to 30% of people with PsV eventually develop psoriatic arthritis (PsA), an inflammatory musculoskeletal condition. To discern differences in genetic risk factors for PsA and cutaneous-only psoriasis (PsC), we carried out a genome-wide association study (GWAS) of 1,430 PsA case subjects and 1,417 unaffected control subjects. Meta-analysis of this study with three other GWASs and two targeted genotyping studies, encompassing a total of 9,293 PsV case subjects, 3,061 PsA case subjects, 3,110 PsC case subjects, and 13,670 unaffected control subjects of European descent, detected 10 regions associated with PsA and 11 with PsC at genome-wide (GW) significance. Several of these association signals (IFNLR1, IFIH1, NFKBIA for PsA; TNFRSF9, LCE3C/B, TRAF3IP2, IL23A, NFKBIA for PsC) have not previously achieved GW significance. After replication, we also identified a PsV-associated SNP near CDKAL1 (rs4712528, odds ratio [OR] = 1.16, p = 8.4 x 10(-11)). Among identified psoriasis risk variants, three were more strongly associated with PsC than PsA (rs12189871 near HLA-C, p = 5.0 x 10(-19); rs4908742 near TNFRSF9, p = 0.00020; rs10888503 near LCE3A, p = 0.0014), and two were more strongly associated with PsA than PsC (rs12044149 near IL23R, p = 0.00018; rs9321623 near TNFAIP3, p = 0.00022). The PsA-specific variants were independent of previously identified psoriasis variants near IL23R and TNFAIP3. We also found multiple independent susceptibility variants in the IL12B, NOS2, and IFIH1 regions. These results provide insights into the pathogenetic similarities and differences between PsC and PsA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
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- art (ämneskategori)
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Stuart, Philip E ...
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Nair, Rajan P.
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Tsoi, Lam C.
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Tejasvi, Trilokr ...
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Das, Sayantan
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Min Kang, Hyun
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visa fler...
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Ellinghaus, Eva
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Chandran, Vinod
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Callis-Duffin, K ...
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Ike, Robert
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Li, Yanming
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Wen, Xiaoquan
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Enerbäck, Charlo ...
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Gudjonsson, Joha ...
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Koks, Sulev
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Kingo, Kuelli
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Esko, Tonu
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Mrowietz, Ulrich
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Reis, Andre
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Erich Wichmann, ...
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Gieger, Christia ...
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Hoffmann, Per
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Noethen, Markus ...
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Winkelmann, Juli ...
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Kunz, Manfred
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Moreta, Elvia G.
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Mease, Philip J.
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Ritchlin, Christ ...
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Bowcock, Anne M.
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Krueger, Gerald ...
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Lim, Henry W.
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Weidinger, Steph ...
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Weichenthal, Mic ...
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Voorhees, John J ...
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Rahman, Proton
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Gregersen, Peter ...
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Franke, Andre
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Gladman, Dafna D ...
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Abecasis, Goncal ...
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Elder, James T.
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