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Metallothionein and...
Metallothionein and Fas (CD95) are expressed in squamous cell carcinoma of the tongue
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- Sundelin, Kaarina (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet,Öronkliniken US
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Jadner, M. (författare)
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- Norberg-Spaak, Lena (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet,Öronkliniken US
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- Davidsson, A. (författare)
- Department of Otorhinolaryngology, Örebro Medical Center Hospital, Örebro, Sweden
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Hellquist, H.B. (författare)
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Eur, J. (författare)
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(creator_code:org_t)
- 1997
- 1997
- Engelska.
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Ingår i: European Journal of Cancer. - 0959-8049. ; 33:11, s. 1860-1864
- Relaterad länk:
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http://urn.kb.se/res...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Metallothionein (MT) is a chelator present in myoepithelial cells, whilst the Fas-receptor (APO-1, CD95) has been described primarily in human T Jurkat cells. 20 cases of carcinoma of the tongue were investigated immunocytochemically with regard to MT, Fas and Bcl-2. In normal oral squamous epithelium, MT is located in the basal/parabasal dividing cells only. In well-differentiated nests of carcinomas, MT is observed almost entirely in peripherally located cells. In situ end-labelling indicates apoptosis in the centre of these nests, but not in the peripheral areas. Less-differentiated areas show more general MT-positivity, but little apoptosis. All 24 tumours are Fas-positive, but normal epithelia are mainly negative (P< 0.0001). Bcl-2 protein was sparse in the tumours compared with MT and Fas (P< 0.0001). We thus suggest that MT, possibly due to its chelating properties, may contribute to delaying cells entering apoptosis, both in normal epithelium near the base and in less-differentiated regions of carcinoma. Moreover, Fas may be present in cells of human malignancies, as well as those of established malignant cell lines.
Nyckelord
- apoptosis
- Bcl-2
- carcinoma squamous cell
- chelator
- Fas
- metallothionein
- tongue
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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