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Hereditary Angioede...
Hereditary Angioedema in Swedish Adults: Report From the National Cohort
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- Nordenfelt, Patrik (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,County Hospital Ryhov, Sweden
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- Nilsson, Mats (författare)
- Futurum, Sweden
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- Björkander, Jan Fredrik (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Futurum, Sweden
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- Mallbris, Lotus (författare)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Lindfors, Anders (författare)
- Karolinska Institutet,Astrid Lindgren Childrens Hospital, Sweden
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- Wahlgren, Carl-Fredrik (författare)
- Karolinska Institutet,Karolinska Institute, Sweden; Karolinska University Hospital, Sweden
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(creator_code:org_t)
- ACTA DERMATO-VENEREOLOGICA, 2016
- 2016
- Engelska.
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Ingår i: Acta Dermato-Venereologica. - : ACTA DERMATO-VENEREOLOGICA. - 0001-5555 .- 1651-2057. ; 96:4, s. 540-545
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://www.medicalj...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Hereditary angioedema (HAE) is rare, disabling and sometimes life-threatening. The aim of this study is to describe its prevalence, symptomatology and treatment in Sweden. A total of 146 patients were identified; 110 adults and 36 children with HAE type I (n = 136) or II (n = 10), giving a minimum HAE prevalence of 1.54/100,000. All patients received a written questionnaire followed by a structured telephone interview. This report focuses on the 102 adults who responded. Females reported 19 attacks in the previous year vs. 9 for males (p < 0.01), and females reported 10 days of sick leave vs. 4 days for males (p < 0.05). For all treated acute attacks, plasma-derived Cl-inhibitor concentrate (pdClINH) (used in 27% of patients) had a good effect. For maintenance treatment, 43% used attenuated androgens and 8% used pdClINH, which reduced their attack rate by more than 50%. In conclusion, the minimum HAE prevalence in Sweden was 1.54/100,000. HAE affected females more severely. Attenuated androgens and pdClINH had a good effect on preventing attacks.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Nyckelord
- Clinhibitor deficiency; census; clinical manifestations; epidemiology; hereditary angioedema; prevalence; Sweden
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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