Sökning: id:"swepub:oai:DiVA.org:liu-129986" >
Q-space trajectory ...
Q-space trajectory imaging for multidimensional diffusion MRI of the human brain
-
- Westin, Carl-Fredrik (författare)
- Linköping University,Linköpings universitet,Medicinsk informatik,Tekniska fakulteten,Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
-
- Knutsson, Hans (författare)
- Linköping University,Linköpings universitet,Medicinsk informatik,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Tekniska fakulteten
-
- Pasternak, Ofer (författare)
- Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
-
visa fler...
-
- Szczepankiewicz, Filip (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Multidimensional microstructure imaging,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Department of Medical Radiation Physics, Lund University, Lund, Sweden
-
- Özarslan, Evren (författare)
- Linköpings universitet,Institutionen för medicinsk teknik,Tekniska fakulteten,Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Physics, Bogazici University, Istanbul, Turkey
-
- van Westen, Danielle (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups,Department of Diagnostic Radiology, Lund University, Lund, Sweden
-
- Mattisson, Cecilia (författare)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Sciences, Psychiatry, Lund University, Lund, Sweden
-
- Bogren, Mats (författare)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Sciences, Psychiatry, Lund University, Lund, Sweden
-
- O'Donnell, Lauren J (författare)
- Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
-
- Kubicki, Marek (författare)
- Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
-
- Topgaard, Daniel (författare)
- Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Division of Physical Chemistry, Department of Chemistry, Lund University, Lund, Sweden
-
- Nilsson, Markus (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund University Bioimaging Center,MR Physics,Forskargrupper vid Lunds universitet,Multidimensional microstructure imaging,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Lund University Bioimaging Center, Lund University, Lund, Sweden
-
visa färre...
-
(creator_code:org_t)
- Elsevier, 2016
- 2016
- Engelska.
-
Ingår i: NeuroImage. - : Elsevier. - 1053-8119 .- 1095-9572. ; 135, s. 345-362
- Relaterad länk:
-
https://europepmc.or...
-
visa fler...
-
http://www.ncbi.nlm....
-
http://dx.doi.org/10...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
visa färre...
Abstract
Ämnesord
Stäng
- This work describes a new diffusion MR framework for imaging and modeling of microstructure that we call q-space trajectory imaging (QTI). The QTI framework consists of two parts: encoding and modeling. First we propose q-space trajectory encoding, which uses time-varying gradients to probe a trajectory in q-space, in contrast to traditional pulsed field gradient sequences that attempt to probe a point in q-space. Then we propose a microstructure model, the diffusion tensor distribution (DTD) model, which takes advantage of additional information provided by QTI to estimate a distributional model over diffusion tensors. We show that the QTI framework enables microstructure modeling that is not possible with the traditional pulsed gradient encoding as introduced by Stejskal and Tanner. In our analysis of QTI, we find that the well-known scalar b-value naturally extends to a tensor-valued entity, i.e., a diffusion measurement tensor, which we call the b-tensor. We show that b-tensors of rank 2 or 3 enable estimation of the mean and covariance of the DTD model in terms of a second order tensor (the diffusion tensor) and a fourth order tensor. The QTI framework has been designed to improve discrimination of the sizes, shapes, and orientations of diffusion microenvironments within tissue. We derive rotationally invariant scalar quantities describing intuitive microstructural features including size, shape, and orientation coherence measures. To demonstrate the feasibility of QTI on a clinical scanner, we performed a small pilot study comparing a group of five healthy controls with five patients with schizophrenia. The parameter maps derived from QTI were compared between the groups, and 9 out of the 14 parameters investigated showed differences between groups. The ability to measure and model the distribution of diffusion tensors, rather than a quantity that has already been averaged within a voxel, has the potential to provide a powerful paradigm for the study of complex tissue architecture.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Nyckelord
- DDE
- DTI
- Diffusion MRI
- Diffusion tensor distribution
- Microscopic anisotropy
- Microscopic fractional anisotropy μFA
- QTI
- SDE
- TDE
- q-space
- q-space trajectory
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Westin, Carl-Fre ...
-
Knutsson, Hans
-
Pasternak, Ofer
-
Szczepankiewicz, ...
-
Özarslan, Evren
-
van Westen, Dani ...
-
visa fler...
-
Mattisson, Cecil ...
-
Bogren, Mats
-
O'Donnell, Laure ...
-
Kubicki, Marek
-
Topgaard, Daniel
-
Nilsson, Markus
-
visa färre...
- Om ämnet
-
- TEKNIK OCH TEKNOLOGIER
-
TEKNIK OCH TEKNO ...
-
och Medicinteknik
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Radiologi och bi ...
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Fysik
-
och Annan fysik
- Artiklar i publikationen
-
NeuroImage
- Av lärosätet
-
Linköpings universitet
-
Lunds universitet