European COMPARative Effectiveness research on blended Depression treatment versus treatment-as-usual (E-COMPARED): study protocol for a randomized controlled, non-inferiority trial in eight European countries

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European COMPARative Effectiveness research on blended Depression treatment versus treatment-as-usual (E-COMPARED): study protocol for a randomized controlled, non-inferiority trial in eight European countries

Kleiboer, A (författare): Section Clinical Psychology, Vrije Universiteit Amsterdam and EMGO+ Institute for Health Care and Research, Amsterdam, The Netherlands

Smit, J (författare): Department of Psychiatry, VU University Medical Centre and EMGO+ Institute for Health Care and Research, Amsterdam, The Netherlands

Bosmans, J (författare): Department of Health Sciences, Vrije Universiteit Amsterdam and EMGO+ Institute for Health and Care Research, Amsterdam, The Netherlands

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Ruwaard, J (författare): Section Clinical Psychology, Vrije Universiteit Amsterdam and EMGO+ Institute for Health Care and Research, Amsterdam, The Netherlands

Andersson, Gerhard (författare): Karolinska Institutet,Linköpings universitet,Psykologi,Filosofiska fakulteten,Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet

Topooco, Naira (författare): Linköpings universitet,Psykologi,Filosofiska fakulteten,Institutet för handikappvetenskap (IHV)

Berger, T (författare): Department of Clinical Psychology and Psychotherapy, University of Bern, Bern, Switzerland

Krieger, T (författare): Department of Clinical Psychology and Psychotherapy, University of Bern, Bern, Switzerland

Botella, C (författare): Department of Psychology and Technology, Jaume University, Castellon, Spain.; Department of Personalidad, Evaluación y Tratamiento Psicológicos, Valencia, Spain

Baños, R (författare): Department of Personalidad, Evaluación y Tratamiento Psicológicos, Valencia, Spain

Chevreul, K (författare): URC-ECO, Ile-de-France (AP-HP), Paris, France

Araya, R (författare): Department of Population Health, London School of Hygiene and Tropical Medicine, London, UK,Department of Psychology, Szkoła Wyzsza Psychologii Społeczne, University of Social Sciences and Humanities, Warsaw, Poland

Cerga-Pashoja, A (författare): Department of Population Health, London School of Hygiene and Tropical Medicine, London, UK

Cieślak, R (författare): Department of Psychology, Szkoła Wyzsza Psychologii Społeczne, University of Social Sciences and Humanities, Warsaw, Poland

Rogala, A (författare): Department of Psychology, Szkoła Wyzsza Psychologii Społeczne, University of Social Sciences and Humanities, Warsaw, Poland

Vis, C (författare): Section Clinical Psychology, Vrije Universiteit Amsterdam and EMGO+ Institute for Health Care and Research, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands

Draisma, S (författare): Department of Psychiatry, VU University Medical Centre and EMGO+ Institute for Health Care and Research, Amsterdam, The Netherlands

van Schaik, A (författare): Department of Psychiatry, VU University Medical Centre and EMGO+ Institute for Health Care and Research, Amsterdam, The Netherlands

Kemmeren, L (författare): Department of Psychiatry, VU University Medical Centre and EMGO+ Institute for Health Care and Research, Amsterdam, The Netherlands

Ebert, D (författare): Department of Clinical Psychology, Philipps University, Marburg, Germany

Berking, M (författare): Department of Clinical Psychology, Philipps University, Marburg, Germany

Funk, B (författare): Institut für elektronische Geschäftsprozesse, Leuphana University Lüneburg, Lüneburg, Germany

Cuijpers, P (författare): Section Clinical Psychology, Vrije Universiteit Amsterdam and EMGO+ Institute for Health Care and Research, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands

Riper, H (författare): Section Clinical Psychology, Vrije Universiteit Amsterdam and EMGO+ Institute for Health Care and Research, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.; Department of Psychiatry, VU University Medical Centre and EMGO+ Institute for Health Care and Research, Amsterdam, The Netherlands

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2016-08-03
2016
Engelska.
Ingår i: Trials. - London : BioMed Central. - 1745-6215. ; 17:1

Relaterad länk:: https://liu.diva-por... (primary) (Raw object); visa fler...; https://trialsjourna...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Background: Effective, accessible, and affordable depression treatment is of high importance considering the large personal and economic burden of depression. Internet-based treatment is considered a promising clinical and cost-effective alternative to current routine depression treatment strategies such as face-to-face psychotherapy. However, it is not clear whether research findings translate to routine clinical practice such as primary or specialized mental health care. The E-COMPARED project aims to gain knowledge on the clinical and cost-effectiveness of blended depression treatment compared to treatment-as-usual in routine care.Methods/design: E-COMPARED will employ a pragmatic, multinational, randomized controlled, non-inferiority trial in eight European countries. Adults diagnosed with major depressive disorder (MDD) will be recruited in primary care (Germany, Poland, Spain, Sweden, and the United Kingdom) or specialized mental health care (France, The Netherlands, and Switzerland). Regular care for depression is compared to "blended" service delivery combining mobile and Internet technologies with face-to-face treatment in one treatment protocol. Participants will be followed up at 3, 6, and 12 months after baseline to determine clinical improvements in symptoms of depression (primary outcome: Patient Health Questionnaire-9), remission of depression, and cost-effectiveness. Main analyses will be conducted on the pooled data from the eight countries (n = 1200 in total, 150 participants in each country).Discussion: The E-COMPARED project will provide mental health care stakeholders with evidence-based information and recommendations on the clinical and cost-effectiveness of blended depression treatment.Trial Registration: France: ClinicalTrials.gov NCT02542891 . Registered on 4 September 2015; Germany: German Clinical Trials Register DRKS00006866 . Registered on 2 December 2014; The Netherlands: Netherlands Trials Register NTR4962 . Registered on 5 January 2015; Poland: ClinicalTrials.Gov NCT02389660 . Registered on 18 February 2015; Spain: ClinicalTrials.gov NCT02361684 . Registered on 8 January 2015; Sweden: ClinicalTrials.gov NCT02449447 . Registered on 30 March 2015; Switzerland: ClinicalTrials.gov NCT02410616 . Registered on 2 April 2015; United Kingdom: ISRCTN registry, ISRCTN12388725 . Registered on 20 March 2015.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)

Nyckelord

Internet-based treatment
Depression
Cognitive behavioral treatment (CBT)
Blended treatment
Comparative effectiveness research (CER)
Cost-effectiveness
Randomized controlled trial (RCT)
Adults
iCBT
eHealth

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Av författaren/redakt...: Kleiboer, A; Smit, J; Bosmans, J; Ruwaard, J; Andersson, Gerha ...; Topooco, Naira; visa fler...; Berger, T; Krieger, T; Botella, C; Baños, R; Chevreul, K; Araya, R; Cerga-Pashoja, A; Cieślak, R; Rogala, A; Vis, C; Draisma, S; van Schaik, A; Kemmeren, L; Ebert, D; Berking, M; Funk, B; Cuijpers, P; Riper, H; visa färre...

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