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OnabotulinumtoxinA ...
OnabotulinumtoxinA Improves Pain in Patients With Post-Stroke Spasticity: Findings From a Randomized, Double-Blind, Placebo-Controlled Trial
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- Wissel, Joerg (författare)
- Vivantes Klinikum Spandau, Germany
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- Ganapathy, Vaidyanathan (författare)
- Sunovion Pharmaceut Inc, MA USA
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- Ward, Anthony B. (författare)
- Haywood Hospital, England
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- Borg, Jorgen (författare)
- Karolinska Institutet
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- Ertzgaard, Per (författare)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för samhällsmedicin,Region Östergötland, Rehabiliteringsmedicinska kliniken
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- Herrmann, Christoph (författare)
- Asklepios Kliniken Schildautal, Germany
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- Häggstrom, Anders (författare)
- Örebro University Hospital, Sweden
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- Sakel, Mohamed (författare)
- East Kent University Hospital NHS, England
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- Ma, Julia (författare)
- Allergan Plc, CA 92612 USA
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- Dimitrova, Rozalina (författare)
- Allergan Plc, CA 92612 USA
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- Fulford-Smith, Antony (författare)
- Marlow Int, England
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- Gillard, Patrick (författare)
- Allergan Plc, CA 92612 USA
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(creator_code:org_t)
- ELSEVIER SCIENCE INC, 2016
- 2016
- Engelska.
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Ingår i: Journal of Pain and Symptom Management. - : ELSEVIER SCIENCE INC. - 0885-3924 .- 1873-6513. ; 52:1, s. 17-26
- Relaterad länk:
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http://www.jpsmjourn...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Context. Patients with post-stroke spasticity (PSS) commonly experience pain in affected limbs, which may impact quality of life. Objectives. To assess onabotulinumtoxinA for pain in patients with PSS from the BOTOX (R) Economic Spasticity Trial, a multicenter, randomized, double-blind, placebo-controlled trial. Methods. Patients with PSS (N = 273) were randomized to 22- to 34-week double-blind treatment with onabotulinumtoxinA + standard care (SC) or placebo injection + SC and were eligible to receive open-label onabotulinumtoxinA up to 52 weeks. Assessments included change from baseline on the 11-point pain numeric rating scale, proportion of patients with baseline pain amp;gt;= 4 achieving amp;gt;= 30% and amp;gt;= 50% improvement in pain, and pain interference with work at Week 12, end of double-blind treatment, and Week 52. Results. At baseline, most patients (74.3%) experienced pain and 47.4% had pain amp;gt;= 4 (pain subgroup). Mean pain reduction from baseline at Week 12 was significantly greater with onabotulinumtoxinA + SC (-0.77, 95% CI -1.14 to -0.40) than placebo + SC (-0.13, 95% CI -0.51 to 0.24; P amp;lt; 0.05). Higher proportions of patients in the pain subgroup achieved amp;gt;= 30% and amp;gt;= 50% reductions in pain at Week 12 with onabotulinumtoxinA + SC (53.7% and 37.0%, respectively) compared with placebo (28.8% and 18.6%, respectively; P amp;lt; 0.05). Reductions in pain were sustained through Week 52. Compared with placebo + SC, onabotulinumtoxinA consistently reduced pain interference with work. Conclusion. This is the first randomized, placebo-controlled trial demonstrating statistically significant and clinically meaningful reductions in pain and pain interference with work with onabotulinumtoxinA in patients with PSS. (C) 2016 The Authors. Published by Elsevier Inc. on behalf of American Academy of Hospice and Palliative Medicine. This is an open access article under the CC BY-NC-ND license.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Övrig annan medicin och hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Other Medical and Health Sciences not elsewhere specified (hsv//eng)
Nyckelord
- OnabotulinumtoxinA; pain; post-stroke spasticity; disability
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Wissel, Joerg
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Ganapathy, Vaidy ...
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Ward, Anthony B.
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Borg, Jorgen
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Ertzgaard, Per
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Herrmann, Christ ...
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Häggstrom, Ander ...
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Sakel, Mohamed
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Ma, Julia
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Dimitrova, Rozal ...
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Fulford-Smith, A ...
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Gillard, Patrick
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Annan medicin oc ...
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och Övrig annan medi ...
- Artiklar i publikationen
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Journal of Pain ...
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet