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Up-regulation of Bo...
Up-regulation of Borrelia-specific IL-4 and IFN-gamma secreting cells in cerebrospinal fluid from children with Lyme neuroborreliosis
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- Widhe, Mona (författare)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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- Hedin Skogman, Barbro (författare)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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- Bergström, Sven (författare)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Bergström,Department of Microbiology, University of Umeå, Sweden
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- Forsberg, Pia (författare)
- Linköpings universitet,Infektionsmedicin,Hälsouniversitetet
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- Ernerudh, Jan (författare)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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- Jarefors, Sara (författare)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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- Eknefelt, Mattias (författare)
- Pediatric Clinic, Ryhov County Hospital, Jönköping, Sweden
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- Eneström, Gunilla (författare)
- Pediatric Clinic, Västervik Hospital, Västervik, Sweden
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- Nordwall, Maria (författare)
- Pediatric Clinic, Vrinnevi Hospital, Norrköping, Sweden
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- Ekerfelt, Christina (författare)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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- Croner, Stefan (författare)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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(creator_code:org_t)
- 2005-09-13
- 2005
- Engelska.
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Ingår i: International Immunology. - : Oxford University Press (OUP). - 0953-8178 .- 1460-2377. ; 17:10, s. 1283-1291
- Relaterad länk:
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http://urn.kb.se/res...
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https://academic.oup...
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The clinical course and outcome of several infectious diseases are dependent on the type of immune response elicited against the pathogen. In adults with neuroborreliosis (NB), a type 1 response with high production of Borrelia-specific IFN-, but no IL-4, has been reported. Since children have a more benign course of NB than adults, we wanted to investigate type 1 and type 2 responses in children with NB. Cerebrospinal fluid (CSF) and blood were collected from children during the acute stage of ‘confirmed NB’ (n = 34), ‘possible NB’ (n = 30) and ‘non-NB’ (n = 10). The number of Borrelia-specific IL-4- and IFN--secreting cells was measured by enzyme-linked immunospot assay. Borrelia-specific secretion of both IL-4 and IFN- was increased in CSF in confirmed (P < 0.05) and possible (P < 0.01) NB, when compared with non-NB controls. Furthermore, children with NB had significantly higher Borrelia-specific IL-4 secretion in CSF than an adult reference material with NB (P < 0.05). There were no differences in cytokine secretion in relation to onset or recovery of neurological symptoms. Since IL-4 is known to down-regulate the pro-inflammatory and possibly harmful effects of prolonged IFN- responses, the prominent IL-4 response observed in the central nervous system compartment might contribute to the more benign disease course seen in children with Lyme NB.
Nyckelord
- cytokines
- IL-4
- IFN-{gamma}
- immune response
- ELISPOT
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Widhe, Mona
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Hedin Skogman, B ...
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Bergström, Sven
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Forsberg, Pia
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Ernerudh, Jan
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Jarefors, Sara
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Eknefelt, Mattia ...
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Eneström, Gunill ...
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Nordwall, Maria
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Ekerfelt, Christ ...
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Croner, Stefan
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Linköpings universitet
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Umeå universitet