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Negative Checkpoint...
Negative Checkpoint Regulatory Molecule 2B4 (CD244) Upregulation Is Associated with Invariant Natural Killer T Cell Alterations and Human Immunodeficiency Virus Disease Progression
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- Ahmad, Fareed (författare)
- Hannover Medical Sch, Germany
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- Shankar, Esaki M. (författare)
- University of Malaya, Malaysia; University of Malaya, Malaysia; School Basic Appl Science, India
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- Yong, Yean K. (författare)
- University of Malaya, Malaysia
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- Tan, Hong Y. (författare)
- University of Malaya, Malaysia
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- Ahrenstorf, Gerrit (författare)
- Hannover Medical Sch, Germany
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- Jacobs, Roland (författare)
- Hannover Medical Sch, Germany
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- Larsson, Marie (författare)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Schmidt, Reinhold E. (författare)
- Hannover Medical Sch, Germany
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- Kamarulzaman, Adeeba (författare)
- University of Malaya, Malaysia; University of Malaya, Malaysia
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- Ansari, Abdul W. (författare)
- University of Malaya, Malaysia; University of Malaya, Malaysia
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(creator_code:org_t)
- 2017-03-27
- 2017
- Engelska.
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Ingår i: Frontiers in Immunology. - : FRONTIERS MEDIA SA. - 1664-3224. ; 8
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- The CD1d-restricted invariant natural killer T (iNKT) cells are implicated in innate immune responses against human immunodeficiency virus (HIV). However, the determinants of cellular dysfunction across the iNKT cells subsets are seldom defined in HIV disease. Herein, we provide evidence for the involvement of the negative checkpoint regulator (NCR) 2B4 in iNKT cell alteration in a well-defined cohort of HIV-seropositive anti-retroviral therapy (ART) naive, ART-treated, and elite controllers (ECs). We report on exaggerated 2B4 expression on iNKT cells of HIV-infected treatment-naive individuals. In sharp contrast to CD4-iNKT cells, 2B4 expression was significantly higher on CD4+ iNKT cell subset. Notably, an increased level of 2B4 on iNKT cells was strongly correlated with parameters associated with HIV disease progression. Further, iNKT cells from ARTnaive individuals were defective in their ability to produce intracellular IFN-gamma Together, our results suggest that the levels of 2B4 expression and the downstream co-inhibitory signaling events may contribute to impaired iNKT cell responses.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Nyckelord
- invariant natural killer T cells; 2B4; human immunodeficiency virus; inhibitory; IFN-gamma; CD4
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ahmad, Fareed
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Shankar, Esaki M ...
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Yong, Yean K.
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Tan, Hong Y.
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Ahrenstorf, Gerr ...
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Jacobs, Roland
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visa fler...
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Larsson, Marie
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Schmidt, Reinhol ...
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Kamarulzaman, Ad ...
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Ansari, Abdul W.
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Immunologi
- Artiklar i publikationen
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Frontiers in Imm ...
- Av lärosätet
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Linköpings universitet