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Vitamin D status in...
Vitamin D status in young Swedish women with anorexia nervosa during intensive weight gain therapy
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- Svedlund, Anna (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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- Pettersson, Cecilia, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Tubić, Bojan, 1984 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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- Magnusson, Per (författare)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Region Östergötland, Klinisk kemi
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- Swolin-Eide, Diana, 1968 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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(creator_code:org_t)
- 2016-06-15
- 2017
- Engelska.
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Ingår i: European Journal of Nutrition. - : SPRINGER HEIDELBERG. - 1436-6207 .- 1436-6215. ; 56:6, s. 2061-2067
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Purpose Anorexia nervosa (AN) is associated with reduced bone mass and an increased fracture risk. The aim was to evaluate the vitamin D status and the association with body mass index (BMI), fat mass and bone mineral density (BMD) in patients with severe AN during a prospective intervention study of intensive nutrition therapy. Methods This study comprised 25 Swedish female AN patients (20.1 +/- 2.3 years), who were treated as inpatients for 12 weeks with a high-energy diet. Serum 25-hydroxy-vitamin D (25(OH) D), calcium, phosphate and parathyroid hormone (PTH) were measured. BMD and body composition were assessed by dual-energy X-ray absorptiometry at study start and after 12 weeks. Results Twenty-two patients completed the study. The mean weight gain was 9.9 kg and BMI (mean +/- SD) increased from 15.5 +/- 0.9 to 19.0 +/- 0.9 kg/m(2), P amp;lt; 0.0001. Fat mass increased from median 12 to 27 %. The median serum 25(OH) D level was 84 nmol/L at baseline, which decreased to 76 nmol/L, P amp;lt; 0.05. PTH increased from median 21.9 to 30.0 ng/L, P amp;lt; 0.0001. BMC increased during the study period, P amp;lt; 0.001. Conclusions Serum 25(OH) D levels were adequate both at study start and completion, however, nominally decreased after the 12-week nutritional intervention. PTH increased subsequently, which coincide with the decreased 25(OH) D levels. The reduction in 25(OH) D could be due to an increased storage of vitamin D related to the increase in fat mass since vitamin D is sequestered in adipose tissue.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Vitamin D; Anorexia nervosa; Nutrition therapy; Bone
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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