Sökning: id:"swepub:oai:DiVA.org:liu-141654" >
Compromised intesti...
Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis
-
- Khounlotham, Manirath (författare)
- Epithelial Pathobiology and Mucosal Inflammation Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
-
- Kim, Wooki (författare)
- Epithelial Pathobiology and Mucosal Inflammation Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
-
- Peatman, Eric (författare)
- Epithelial Pathobiology and Mucosal Inflammation Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
-
visa fler...
-
- Nava, Porfirio (författare)
- Epithelial Pathobiology and Mucosal Inflammation Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
-
- Medina-Contreras, Oscar (författare)
- Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
-
- Addis, Caroline (författare)
- Epithelial Pathobiology and Mucosal Inflammation Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
-
- Koch, Stefan (författare)
- Epithelial Pathobiology and Mucosal Inflammation Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
-
- Fournier, Benedicte (författare)
- Epithelial Pathobiology and Mucosal Inflammation Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
-
- Nusrat, Asma (författare)
- Epithelial Pathobiology and Mucosal Inflammation Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
-
- Denning, Timothy L. (författare)
- Epithelial Pathobiology and Mucosal Inflammation Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
-
- Parkos, Charles A. (författare)
- Epithelial Pathobiology and Mucosal Inflammation Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
-
visa färre...
-
(creator_code:org_t)
- Cambridge, United States : Cell Press, 2012
- 2012
- Engelska.
-
Ingår i: Immunity. - Cambridge, United States : Cell Press. - 1074-7613 .- 1097-4180. ; 37:3, s. 563-573
- Relaterad länk:
-
http://www.cell.com/...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Mice lacking junctional adhesion molecule A (JAM-A, encoded by F11r) exhibit enhanced intestinal epithelial permeability, bacterial translocation, and elevated colonic lymphocyte numbers, yet do not develop colitis. To investigate the contribution of adaptive immune compensation in response to increased intestinal epithelial permeability, we examined the susceptibility of F11r(-/-)Rag1(-/-) mice to acute colitis. Although negligible contributions of adaptive immunity in F11r(+/+)Rag1(-/-) mice were observed, F11r(-/-)Rag1(-/-) mice exhibited increased microflora-dependent colitis. Elimination of T cell subsets and cytokine analyses revealed a protective role for TGF-beta-producing CD4(+) T cells in F11r(-/-) mice. Additionally, loss of JAM-A resulted in elevated mucosal and serum IgA that was dependent upon CD4(+) T cells and TGF-beta. Absence of IgA in F11r(+/+)Igha(-/-) mice did not affect disease, whereas F11r(-/-)Igha(-/-) mice displayed markedly increased susceptibility to acute injury-induced colitis. These data establish a role for adaptive immune-mediated protection from acute colitis under conditions of intestinal epithelial barrier compromise.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Adaptive Immunity/genetics/*immunology
- Animals
- Bacterial Translocation/genetics/immunology
- CD4-Positive T-Lymphocytes/immunology/metabolism
- Cell Adhesion Molecules/genetics/immunology
- Colitis/chemically induced/genetics/*immunology
- Dextran Sulfate
- Epithelium/immunology/metabolism
- Female
- Flow Cytometry
- Gene Expression
- Homeodomain Proteins/genetics/immunology
- Immunoglobulin A/genetics/immunology
- Intestinal Mucosa/*immunology/metabolism/microbiology
- Intestines/*immunology/metabolism/microbiology
- Male
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- Permeability
- Receptors
- Cell Surface/genetics/immunology
- Reverse Transcriptase Polymerase Chain Reaction
- Transforming Growth Factor beta/genetics/immunology/metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Immunity
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Khounlotham, Man ...
-
Kim, Wooki
-
Peatman, Eric
-
Nava, Porfirio
-
Medina-Contreras ...
-
Addis, Caroline
-
visa fler...
-
Koch, Stefan
-
Fournier, Benedi ...
-
Nusrat, Asma
-
Denning, Timothy ...
-
Parkos, Charles ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Cell och molekyl ...
- Artiklar i publikationen
-
Immunity
- Av lärosätet
-
Linköpings universitet