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JAM-A regulates epi...
JAM-A regulates epithelial proliferation through Akt/beta-catenin signalling
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- Nava, Porfirio (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
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- Capaldo, Christopher T. (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
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- Koch, Stefan (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
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- Kolegraff, Keli (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
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- Rankin, Carl Robert (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
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- Farkas, Attila E. (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA; Institute of Biophysics, Biological Research Center, Szeged, Hungary
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- Feasel, Mattie E. (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
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- Li, Linheng (författare)
- Stowers Institute for Medical Research, Kansas City, Missouri, USA
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- Addis, Caroline (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
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- Parkos, Charles A. (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
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- Nusrat, Asma (författare)
- Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Whitehead Biomedical Research Building, Atlanta, Georgia, USA
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(creator_code:org_t)
- 2011-03-04
- 2011
- Engelska.
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Ingår i: EMBO Reports. - : Wiley-Blackwell Publishing Inc.. - 1469-221X .- 1469-3178. ; 12:4, s. 314-20
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Expression of the tight junction protein junctional adhesion molecule-A (JAM-A) has been linked to proliferation and tumour progression. However, a direct role for JAM-A in regulating proliferative processes has not been shown. By using complementary in vivo and in vitro approaches, we demonstrate that JAM-A restricts intestinal epithelial cell (IEC) proliferation in a dimerization-dependent manner, by inhibiting Akt-dependent beta-catenin activation. Furthermore, IECs from transgenic JAM-A(-/-)/beta-catenin/T-cell factor reporter mice showed enhanced beta-catenin-dependent transcription. Finally, inhibition of Akt reversed colonic crypt hyperproliferation in JAM-A-deficient mice. These data establish a new link between JAM-A and IEC homeostasis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- junctional adhesion molecule; Akt; b-catenin; cell proliferation; tight junction
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Nava, Porfirio
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Capaldo, Christo ...
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Koch, Stefan
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Kolegraff, Keli
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Rankin, Carl Rob ...
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Farkas, Attila E ...
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visa fler...
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Feasel, Mattie E ...
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Li, Linheng
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Addis, Caroline
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Parkos, Charles ...
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Nusrat, Asma
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visa färre...
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