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Estimation of deliv...
Estimation of delivered dialysis dose by on-line monitoring of the ultraviolet absorbance in the spent dialysate
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- Uhlin, Fredrik (författare)
- Linköpings universitet,Njurmedicin,Hälsouniversitetet
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- Fridolin, Ivo (författare)
- Linköpings universitet,Institutionen för medicinsk teknik,Tekniska högskolan
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- Lindberg, Lars-Göran (författare)
- Linköpings universitet,Institutionen för medicinsk teknik,Tekniska högskolan
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- Magnusson, Martin (författare)
- Linköpings universitet,Njurmedicin,Hälsouniversitetet
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(creator_code:org_t)
- 2003
- 2003
- Engelska.
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Ingår i: American Journal of Kidney Diseases. - 0272-6386 .- 1523-6838. ; 41:5, s. 1026-1036
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background:Several methods are available to determine Kt/V, from predialysis and postdialysis blood samples to using on-line dialysate urea monitors or to ionic dialysance using a conductivity method. The aim of this study is to compare Kt/V calculated from the slope of the logarithmic on-line ultraviolet (UV) absorbance measurements, blood urea Kt/V, dialysate urea Kt/V, and Kt/V from the Urea Monitor 1000 (UM; Baxter Healthcare Corp, Deerfield, IL).Methods:Thirteen uremic patients on chronic thrice-weekly hemodialysis therapy were included in the study. The method uses absorption of UV radiation by means of a spectrophotometric set-up. Measurements were performed on-line with the spectrophotometer connected to the fluid outlet of the dialysis machine; all spent dialysate passed through a specially designed cuvette for optical single-wavelength measurements. UV absorbance measurements were compared with those calculated using blood urea and dialysate urea, and, in a subset of treatments, the UM.Results:Equilibrated Kt/V (eKt/V) obtained with UV absorbance (eKt/Va) was 1.19 ± 0.23; blood urea (eKt/Vb), 1.30 ± 0.20, and dialysate urea (eKt/Vd), 1.26 ± 0.21, and Kt/V in a subset measured by the UM (UM Kt/V) was 1.24 ± 0.18. The difference between eKt/Vb and eKt/Va was 0.10 ± 0.11, showing a variation similar to the difference between eKt/Vb and eKt/Vd (0.03 ± 0.10) and in a subset between eKt/Vb and UM Kt/V (−0.02 ± 0.11).Conclusion:The study suggests that urea Kt/V can be estimated by on-line measurement of UV absorption in the spent dialysate.
Nyckelord
- Hemodialysis (HD)
- dialysis monitoring
- dialysis dose
- spectrophotometry
- absorption
- ultraviolet (UV)
- solute removal
- spent dialysate
- dialysis adequacy
- dialysis efficiency
- urea
- Kt/V
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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