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Targeting cancer cells with controlled release nanocapsules based on a single aptamer

Hernandez, Frank J (author)
Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of of Iowa, Iowa City, IA 52242, United States
Hernandez, Luiza I. (author)
Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of of Iowa, Iowa City, IA 52242, United States
Pinto, Alessandro (author)
NanoBioSeparations Group, POLYMAT, University of of the Basque Country UPV/EHU, Avda. Tolosa 72, Donostia-San-Sebastián, Spain
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Schäfer, Thomas (author)
NanoBioSeparations Group, POLYMAT, University of of the Basque Country UPV/EHU, Avda. Tolosa 72, Donostia-San-Sebastián, Spain; Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain
Özalp, Veli C. (author)
Nanobiz Ltd. Metu Technopolis, 06800 Ankara, Turkey; Middle East Technical University, Biological Sciences, 06800 Ankara, Turkey
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Department of Internal Medicine, Roy J and Lucille A. Carver College of Medicine, University of of Iowa, Iowa City, IA 52242, United States NanoBioSeparations Group, POLYMAT, University of of the Basque Country UPV/EHU, Avda. Tolosa 72, Donostia-San-Sebastián, Spain (creator_code:org_t)
Royal Society of Chemistry, 2013
2013
English.
In: Chemical Communications. - : Royal Society of Chemistry. - 1359-7345 .- 1364-548X. ; 49:13, s. 1285-1287
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Molecular gates have received considerable attention as drug delivery systems. More recently, aptamer-based gates showed great potential in overcoming major challenges associated with drug delivery by means of nanocapsules. Based on a switchable aptamer nanovalves approach, we herein report the first demonstration of an engineered single molecular gate that directs nanoparticles to cancer cells and subsequently delivers the payload in a controllable fashion. © 2012 The Royal Society of Chemistry.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)

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