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Anemia of Inflammat...
Anemia of Inflammation during Human Pregnancy Does Not Affect Newborn Iron Endowment
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- Abioye, Ajibola I. (författare)
- Brown Univ, RI 02912 USA; Rhode Isl Hosp, RI USA; Rhode Isl Hosp, RI USA
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- Park, Sangshin (författare)
- Brown Univ, RI 02912 USA; Rhode Isl Hosp, RI USA; Rhode Isl Hosp, RI USA
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- Ripp, Kelsey (författare)
- Brown Univ, RI 02912 USA
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- McDonald, Emily A. (författare)
- Brown Univ, RI 02912 USA; Rhode Isl Hosp, RI USA; Rhode Isl Hosp, RI USA
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- Kurtis, Jonathan D. (författare)
- Brown Univ, RI 02912 USA; Rhode Isl Hosp, RI USA; Rhode Isl Hosp, RI USA
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- Wu, Hannah (författare)
- Brown Univ, RI 02912 USA; Rhode Isl Hosp, RI USA; Rhode Isl Hosp, RI USA
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- Pond-Tor, Sunthorn (författare)
- Rhode Isl Hosp, RI USA
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- Sharma, Surendra (författare)
- Brown Univ, RI 02912 USA; Women and Infants Hosp Rhode Isl, RI 02908 USA
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- Ernerudh, Jan (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin
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- Baltazar, Palmera (författare)
- Res Inst Trop Med, Philippines; Remedios Trinidad Romualdez Hosp, Philippines
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- Acosta, Luz P. (författare)
- Res Inst Trop Med, Philippines
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- Olveda, Remigio M. (författare)
- Res Inst Trop Med, Philippines
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- Tallo, Veronica (författare)
- Res Inst Trop Med, Philippines
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- Friedman, Jennifer F. (författare)
- Brown Univ, RI 02912 USA; Rhode Isl Hosp, RI USA; Rhode Isl Hosp, RI USA
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(creator_code:org_t)
- AMER SOC NUTRITION-ASN, 2018
- 2018
- Engelska.
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Ingår i: Journal of Nutrition. - : AMER SOC NUTRITION-ASN. - 0022-3166 .- 1541-6100. ; 148:3, s. 427-436
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: To our knowledge, no studies have addressed whether maternal anemia of inflammation (AI) affects newborn iron status, and few have addressed risk factors for specific etiologies of maternal anemia. Objectives: The study aims were to evaluate 1) the contribution of AI and iron deficiency anemia (IDA) to newborn iron endowment, 2) hepcidin as a biomarker to distinguish AI from IDA among pregnant women, and 3) risk factors for specific etiologies of maternal anemia. Methods: We measured hematologic biomarkers in maternal blood at 12 and 32 wk of gestation and in cord blood from a randomized trial of praziquantel in 358 pregnant women with Schistosoma japonicum in The Philippines. IDA was defined as anemia with serum ferritin amp;lt; 30 ng/mL and non-IDA (NIDA), largely due to AI, as anemia with ferritin amp;gt;= 30 ng/mL. We identified cutoffs for biomarkers to distinguish IDA from NIDA by using area under the curve (AUC) analyses and examined the impact of different causes of anemia on newborn iron status (primary outcome) by using multivariate regression modeling. Results: Of the 358 mothers, 38% (n = 136) had IDA and 9% (n = 32) had NIDA at 32 wk of gestation. At 32 wk of gestation, serum hepcidin performed better than soluble transferrin receptor (sTfR) in identifying women with NIDA compared with the rest of the cohort (AUCs: 0.75 and 0.70, respectively) and in identifying women with NIDA among women with anemia (0.73 and 0.72, respectively). The cutoff that optimally distinguished women with NIDA from women with IDA in our cohort was 6.1 mu g/L. Maternal IDA, but not NIDA, was associated with significantly lower newborn ferritin (114.4 ng/mL compared with 148.4 mu g/L; P = 0.042). Conclusions: Hepcidin performed better than sTfR in identifying pregnant women with NIDA, but its cost may limit its use. Maternal IDA, but not NIDA, is associated with decreased newborn iron stores, emphasizing the need to identify this cause and provide iron therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- iron-deficiency anemia; non-iron deficiency anemia; anemia of inflammation; pregnancy; Schistosoma japonicum; biomarker; hepcidin; sTfR
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- ref (ämneskategori)
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Abioye, Ajibola ...
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Park, Sangshin
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Ripp, Kelsey
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McDonald, Emily ...
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Kurtis, Jonathan ...
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Wu, Hannah
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visa fler...
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Pond-Tor, Suntho ...
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Sharma, Surendra
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Ernerudh, Jan
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Baltazar, Palmer ...
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Acosta, Luz P.
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Olveda, Remigio ...
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Tallo, Veronica
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Friedman, Jennif ...
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- MEDICIN OCH HÄLSOVETENSKAP
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Linköpings universitet