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Long-term follow-up...
Long-term follow-up of conservatively managed incidental carcinoma of the prostate A multivariate analysis of prognostic factors
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- Robinson, David, 1968- (författare)
- Section of Urology, Ryhov County Hospital, Jönköping, Sweden
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- Aus, Gunnar (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Urology, Sahlgrens University Hospital, Goumlteborg, Sweden
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- Bak, Julia (författare)
- Linköpings universitet,Institutionen för molekylär och klinisk medicin,Hälsouniversitetet
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- Gorecki, Tomasz (författare)
- County Hospital of Kalmar, Kalmar, Sweden
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- Herder, Anders (författare)
- Linköpings universitet,Institutionen för molekylär och klinisk medicin,Hälsouniversitetet
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- Rosell, Johan (författare)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Varenhorst, Eberhard (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Urologi,Hälsouniversitetet,Urologiska kliniken i Östergötland
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(creator_code:org_t)
- 2009-07-09
- 2007
- Engelska.
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Ingår i: Scandinavian Journal of Urology and Nephrology. - : Informa UK Limited. - 0036-5599 .- 1651-2065. ; 41:2, s. 103-109
- Relaterad länk:
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http://urn.kb.se/res...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Objective: To evaluate the disease-specific mortality of conservatively managed incidental carcinoma of the prostate (T1a and T1b) in relation to prognostic factors. Material and methods: Since 1987 all patients with prostate cancer have been recorded and followed in the population-based Prostate Cancer Register of the South-East Healthcare Region in Sweden, which is covered by four departments of pathology. At two of these departments, tissue was obtained from 197 consecutive, previously untreated patients (aged <80 years) with incidental carcinoma who underwent transurethral resection of the prostate between 1987 and 1991. The amount of tumour, Gleason score and levels of Ki-67, p53, chromogranin A and serotonin were determined. Univariate analysis and multiple Cox regression hazard analysis were used for analysis. Results: During follow-up (mean 7.8 years; maximum 17.5 years), 158 patients (80%) had died, 33 of them of prostate cancer, corresponding to 17% of the entire cohort. Of 86 patients with Gleason score ≤5, three died of prostate cancer. Independent predictors of disease-specific mortality in multivariate analysis were category T1b prostate cancer, Gleason score >5 and high immunoreactivity of Ki-67. Conclusions: Elderly men with category T1a and/or Gleason score 4-5 prostate cancer have a favourable prognosis with conservative management. Immunohistochemical staining with Ki-67 may be of help in situations where further prognostic information is required.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Prostate cancer
- prognostic factors
- incidental carcinoma
- survival
- p53
- Ki-67
- chromogranin A
- Oncology
- Onkologi
- Prostate cancer; prognostic factors; incidental carcinoma; survival; p53; Ki-67; chromogranin A
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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