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Flexible wireless p...
Flexible wireless powered drug delivery system for targeted administration on cerebral cortex
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- Sung, Sang Hyun (författare)
- Korea Adv Inst Sci and Technol, South Korea
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- Kim, Young Soo (författare)
- Korea Adv Inst Sci and Technol, South Korea
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- Joe, Daniel J. (författare)
- Korea Adv Inst Sci and Technol, South Korea
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- Mun, Beom Ho (författare)
- Korea Adv Inst Sci and Technol, South Korea
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- You, Byoung Kuk (författare)
- Korea Adv Inst Sci and Technol, South Korea
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- Keum, Do Hee (författare)
- Pohang Univ Sci and Technol POSTECH, South Korea
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- Hahn, Sei Kwang (författare)
- Pohang Univ Sci and Technol POSTECH, South Korea
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- Berggren, Magnus (författare)
- Linköpings universitet,Fysik och elektroteknik,Tekniska fakulteten
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- Kim, Daesoo (författare)
- Korea Adv Inst Sci and Technol, South Korea
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- Lee, Keon Jae (författare)
- Korea Adv Inst Sci and Technol, South Korea
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(creator_code:org_t)
- ELSEVIER SCIENCE BV, 2018
- 2018
- Engelska.
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Ingår i: Nano Energy. - : ELSEVIER SCIENCE BV. - 2211-2855 .- 2211-3282. ; 51, s. 102-112
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The controlled drug delivery devices helps timely drug administrations and maintenance of effective dose to maximize curing effects with minimal side effects. Application of this technology to various body parts has been limited, especially in organs with curved surface, such as the brain and the eye. Herein, we report a flexible drug delivery microdevice (f-DDM) for controlled administration on the curved organ surface. The unique structure of the f-DDM consists of freestanding gold membranes over the multireservoir array was implemented by reversing the typical fabrication order of the reservoir and sealing membrane. We optimized the design of the f-DDM by a finite element analysis to prevent thermal damage during the laser transfer and the applying current density for reliable drug release through an electrochemical analysis. The wireless power transfer system was applied to f-DDM, which shows stable wirelessly powered operation. The f-DDM was flexible enough to be implantable on the curved cerebral cortex and successfully adopted for delivery of two different chemicals or prevention of seizure activity using an anti-epileptic drug. Our study opens a new avenue for the controlled, region-specific, and combinatorial application of drugs, the key factors for precision medicine.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Maskinteknik -- Energiteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Mechanical Engineering -- Energy Engineering (hsv//eng)
Nyckelord
- Drug delivery; Flexible device; Implantable device; Wireless power transfer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Sung, Sang Hyun
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Kim, Young Soo
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Joe, Daniel J.
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Mun, Beom Ho
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You, Byoung Kuk
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Keum, Do Hee
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visa fler...
-
Hahn, Sei Kwang
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Berggren, Magnus
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Kim, Daesoo
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Lee, Keon Jae
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visa färre...
- Om ämnet
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Maskinteknik
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och Energiteknik
- Artiklar i publikationen
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Nano Energy
- Av lärosätet
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Linköpings universitet