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PIK3CA, HRAS and KR...
PIK3CA, HRAS and KRAS gene mutations in human penile cancer
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- Andersson, Patiyan, 1978- (författare)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet,Division of Cell Biology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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- Kolaric, Aleksandra (författare)
- Departments of Pathology, Örebro University Hospital, Örebro, Sweden
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- Windahl, Torgny (författare)
- Departments of Urology, Örebro University Hospital, Örebro, Sweden
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- Kirrander, Peter, 1978- (författare)
- Departments of Urology, Örebro University Hospital, Örebro, Sweden
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- Söderkvist, Peter (författare)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet,Division of Cell Biology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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- Karlsson, Mats G, 1960- (författare)
- Departments of b Pathology, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- New York, USA : Ovid Technologies (Wolters Kluwer Health), 2008
- 2008
- Engelska.
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Ingår i: Journal of Urology. - New York, USA : Ovid Technologies (Wolters Kluwer Health). - 0022-5347 .- 1527-3792. ; 179:5, s. 2030-2034
- Relaterad länk:
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http://urn.kb.se/res...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Purpose: The knowledge of somatic mutations that arise in penile cancer is limited. We examined the dysregulation of components in the phosphatidylinositol 3-kinase and Ras pathways. Materials and Methods: Using single stranded conformational analysis and direct sequencing we performed mutational analysis of the PIK3CA, PTEN, HRAS, KRAS, NRAS and BRAF genes in 28 penile tumors. Results: We identified somatic missense mutations in 11 of the 28 penile cancer samples (39%). In the PIK3CA gene 8 mutations (29%) were identified that were E542K or E545K. In the HRAS gene a G12S and a Q61L mutation were found (7%). The KRAS gene contained 1 mutation (3%), that is a G12S change. PIK3CA mutations were found in all grades and stages, whereas HRAS and KRAS mutations were found in larger and more advanced tumors. The mutations were mutually exclusive, suggesting that dysregulation of either pathway is sufficient for the development and progression of penile carcinoma. Conclusions: The high frequency of mutations in the PIK3CA, HRAS and KRAS genes leads us to believe that dysregulation of the phosphatidylinositol 3-kinase or Ras pathway is significant for the development and progression of penile carcinoma.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Penis
- penile neoplasms
- mutation
- 1-phosphatidylinositol 3-kinase
- carcinoma
- squamous cell
- Oncology
- Onkologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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