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Radio-frequency les...
Radio-frequency lesioning in brain tissue with coagulation-dependent thermal conductivity : modelling, simulation and analysis of parameter influence and interaction
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- Johansson, Johannes D, 1977- (författare)
- Linköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan,MINT
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- Eriksson, Ola (författare)
- Linköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan
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- Wren, Joakim (författare)
- Linköpings universitet,Mekanisk värmeteori och strömningslära,Tekniska högskolan
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- Loyd, Dan (författare)
- Linköpings universitet,Mekanisk värmeteori och strömningslära,Tekniska högskolan
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- Wårdell, Karin (författare)
- Linköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan,MINT
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(creator_code:org_t)
- 2006-08-29
- 2006
- Engelska.
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Ingår i: Medical and Biological Engineering and Computing. - Heidleberg : Springer. - 0140-0118 .- 1741-0444. ; 44:9, s. 757-766
- Relaterad länk:
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http://urn.kb.se/res...
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http://urn.kb.se/res...
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https://liu.diva-por... (primary) (Raw object)
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http://liu.diva-port...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Radio-frequency brain lesioning is a method for reducing e.g. symptoms of movement disorders. A small electrode is used to thermally coagulate malfunctioning tissue. Influence on lesion size from thermal and electric conductivity of the tissue, microvascular perfusion and preset electrode temperature was investigated using a finite-element model. Perfusion was modelled as an increased thermal conductivity in non-coagulated tissue. The parameters were analysed using a 24-factorial design (n = 16) and quadratic regression analysis (n = 47). Increased thermal conductivity of the tissue increased lesion volume, while increased perfusion decreased it since coagulation creates a thermally insulating layer due to the cessation of blood perfusion. These effects were strengthened with increased preset temperature. The electric conductivity had negligible effect. Simulations were found realistic compared to in vivo experimental lesions.
Nyckelord
- Electrosurgery
- RF ablation
- Brain
- Blood perfusion
- Finite-element method
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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