Sökning: id:"swepub:oai:DiVA.org:liu-159851" >
Striatal Dopamine R...
Striatal Dopamine Release in Response to Morphine: A [C-11]Raclopride Positron Emission Tomography Study in Healthy Men
-
- Spagnolo, Primavera A. (författare)
- NINDS, MD 20892 USA
-
- Kimes, Alane (författare)
- NIDA, MD 20892 USA
-
- Schwandt, Melanie L. (författare)
- NIAAA, MD 20892 USA
-
visa fler...
-
- Shokri-Kojori, Ehsan (författare)
- NIAAA, MD 20892 USA
-
- Thada, Shantalaxmi (författare)
- NIDA, MD 20892 USA
-
- Phillips, Karran A. (författare)
- NIDA, MD 20892 USA
-
- Diazgranados, Nancy (författare)
- NIAAA, MD 20892 USA
-
- Preston, Kenzie L. (författare)
- NIDA, MD 20892 USA; NIDA, MD 20892 USA
-
- Herscovitch, Peter (författare)
- NIDA, MD 20892 USA
-
- Tomasi, Dardo (författare)
- NIAAA, MD 20892 USA
-
- Ramchandani, Vijay A. (författare)
- NIAAA, MD 20892 USA
-
- Heilig, Markus (författare)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken inkl beroendekliniken
-
visa färre...
-
(creator_code:org_t)
- ELSEVIER SCIENCE INC, 2019
- 2019
- Engelska.
-
Ingår i: Biological Psychiatry. - : ELSEVIER SCIENCE INC. - 0006-3223 .- 1873-2402. ; 86:5, s. 356-364
- Relaterad länk:
-
https://www.ncbi.nlm...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Preclinical and human positron emission tomography studies have produced inconsistent results regarding the effects of opioids on mesolimbic dopamine (DA). Here, we quantify striatal DA release (measured by [C-11]raclopride displacement) in response to an intravenous infusion of morphine, and its relationship with morphine-induced subjective effects, in healthy, nondependent opioid-experienced participants. METHODS: Fifteen healthy male participants were initially included. Sessions were on separate days. On session 1, participants received intravenous morphine (10 mg/70 kg) in the clinic to ensure tolerability. Participants without adverse reactions (n = 10) then received intravenous morphine and placebo (saline) sessions, in counterbalanced order, while undergoing [C-11]raclopride positron emission tomography scans. Subjective and physiological responses were assessed. Region-of-interest and voxelwise image analyses were used to assess changes in [C-11]raclopride nondisplaceable binding potential. RESULTS: Morphine produced marked subjective and physiological effects and induced a significant decrease in [C-11]raclopride nondisplaceable binding potential, particularly in the nucleus accumbens and globus pallidus, where the change in [C-11]raclopride nondisplaceable binding potential was approximately 9%. However, the subjective effects of morphine did not show a simple pattern of correlation with DA release. CONCLUSIONS: This is, to our knowledge, the first study providing in vivo human evidence that DA transmission in the ventral striatum is affected by morphine. Further studies are required to fully delineate the DA contribution to the reinforcing effects of opioids.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- [C-11]Raclopride; Dopamine; Morphine; Opioids; PET; Ventral striatum
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Spagnolo, Primav ...
-
Kimes, Alane
-
Schwandt, Melani ...
-
Shokri-Kojori, E ...
-
Thada, Shantalax ...
-
Phillips, Karran ...
-
visa fler...
-
Diazgranados, Na ...
-
Preston, Kenzie ...
-
Herscovitch, Pet ...
-
Tomasi, Dardo
-
Ramchandani, Vij ...
-
Heilig, Markus
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Fysiologi
- Artiklar i publikationen
-
Biological Psych ...
- Av lärosätet
-
Linköpings universitet