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The Influence of Ad...
The Influence of Adjuvant Radiotherapy and Single Nucleotide Polymorphisms on Circulating Immune Response Cell Numbers and Phenotypes of Patients With Breast Cancer
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- Lewin, Nongnit (författare)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Ryhov Hosp, Sweden
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- Luetragoon, Thitiya (författare)
- Ryhov Hosp, Sweden; Naresuan Univ, Thailand
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- Shamoun, Levar (författare)
- Ryhov Hosp, Sweden
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- Oliva, Delmy (författare)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Ryhov Hosp, Sweden
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- Andersson, Bengt-Åke (författare)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Ryhov Hosp, Sweden
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- Lofgren, Sture (författare)
- Ryhov Hosp, Sweden
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- Rutqvist, Lars Erik (författare)
- Swedish Match AB, Sweden
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- Lewin, Freddi (författare)
- Ryhov Hosp, Sweden
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(creator_code:org_t)
- 2019-09-13
- 2019
- Engelska.
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Ingår i: Anticancer Research. - : INT INST ANTICANCER RESEARCH. - 0250-7005 .- 1791-7530. ; 39:9, s. 4957-4963
- Relaterad länk:
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https://ar.iiarjourn...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Background/Aim: Adjuvant radiotherapy (RT) damages multiple layers of skin, muscle, blood vessels and blood cells that are included within the RT area. Indirect, bystander systemic effects could also develop in cells not directly hit by radiation. Materials and Methods: Ninety-three female patients recovering from breast cancer surgery and 82 female healthy blood donors were analyzed. For identification of systemic adaptive and innate immune response, rapid and low-cost blood-based biomarkers were assayed. Results: Post-operated breast cancer patients had a decreased number of circulating adaptive immune response cells but increased number of circulating immunosuppressive myeloid subpopulations. RT decreased the number of T-cells and platelets without influencing the number of immunosuppressive myeloid subpopulations. Alterations in the number and phenotypes of T-cell subpopulations were associated with SNPs. Conclusion: The combination of RT and immunotherapy might provide optimal treatment for cancer patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Breast cancer; radiotherapy; blood-based biomarkers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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