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Subjects with high ...
Subjects with high fasting insulin also have higher postprandial GLP-1 and glucagon levels than controls with lower insulin
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- Albinsson-Stenholm, Erina (författare)
- Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten
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- Bergsen, Johannes (författare)
- Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten
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- Ingues, Simon (författare)
- Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten
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- Vilhelmsson, Nathalie (författare)
- Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten
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- Guldbrand, Hans (författare)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för kardiovaskulär medicin,Region Östergötland, Primärvården i västra länsdelen
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- Nyström, Fredrik H (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Vårdcentralen Cityhälsan Centrum
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(creator_code:org_t)
- PERGAMON-ELSEVIER SCIENCE LTD, 2019
- 2019
- Engelska.
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Ingår i: Nutrition Research. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0271-5317 .- 1879-0739. ; 72, s. 111-120
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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http://liu.diva-port...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Little is known about postprandial release of serum ghrelin, glucagon, and glucagon-like peptide-1 (GLP-1) in relation with differing fasting insulin levels. We hypothesized that these hormones are affected by insulin resistance, and hence, we compared different postprandial responses of GLP-1, glucagon, and ghrelin in subjects with relatively high (RHI) or relatively low (RLI) fasting insulin levels. The trial was a randomized crossover study with 4 different meal conditions. Fourteen nonobese or obese, healthy, men and 14 women were randomly assigned to the order of supervised intake of a 750 kcal drink with the same protein contents but with 20 energy-percent (E%) or 55 E% from carbohydrates, and the remaining energy from fat. Participants were also randomized to consume the drinks as 1 large beverage or as five 150-kcal portions every 30 minutes. The 28 subjects were divided into 2 equally sized groups based on fasting insulin levels. Statistics were done with general linear mixed model. Fasting insulin levels were 3-fold higher in the group with RHI compared with the RLI group (RHI: 1004 +/- 510 pg/mL, RLI: 324 +/- 123 pg/mL, P amp;lt; .0005). Serum GLP-1 was highest in the RHI group after both single meals and after 5 drinks and following high- and low-carbohydrate meals (both P amp;lt;= .002), and this was the case also for glucagon levels (both P amp;lt;= .018), whereas ghrelin levels did not differ between groups. Thus, subjects with RHI displayed both higher postprandial serum GLP-1 and glucagon than the participants with RLI, suggesting that glucagon could play a role in the advent of dysglycemia by insulin resistance. (C) 2019 Elsevier Inc. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Carbohydrate content; Ghrelin; Glucagon; Glucagon-like peptide-1; Satiety; Meal distribution
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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