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Yin Yang 1 Orchestr...
Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation
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- Varum, Sandra (författare)
- University of Zurich, Switzerland
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- Baggiolini, Arianna (författare)
- University of Zurich, Switzerland
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- Zurkirchen, Luis (författare)
- University of Zurich, Switzerland
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- Atak, Zeynep Kalender (författare)
- Laboratory of Computational Biology, Belgium; Department of Human Genetics, Belgium
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- Cantù, Claudio, 1981- (författare)
- University of Zurich, Switzerland
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- Marzorati, Elisa (författare)
- University of Zurich, Switzerland
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- Bossart, Raphaël (författare)
- University of Zurich, Switzerland
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- Wouters, Jasper (författare)
- Laboratory of Computational Biology, Leuven, Belgium; KU Leuven, Leuven, Belgium
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- Häusel, Jessica (författare)
- University of Zurich, Switzerland
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- Tuncer, Eylül (författare)
- University of Zurich, Switzerland
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- Zingg, Daniel (författare)
- University of Zurich, Switzerland
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- Veen, Dominiek (författare)
- University of Zurich, Switzerland
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- John, Nessy (författare)
- University of Zurich, Switzerland
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- Balz, Marcel (författare)
- University of Zurich, Switzerland
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- Levesque, Mitchell P (författare)
- University of Zurich, Switzerland
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- Basler, Konrad (författare)
- University of Zurich, Switzerland
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- Aerts, Stein (författare)
- University of Zurich, Switzerland
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- Zamboni, Nicola (författare)
- University of Zurich, Switzerland
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- Dummer, Reinhard (författare)
- University of Zurich, Switzerland
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- Sommer, Lukas (författare)
- University of Zurich, Switzerland
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(creator_code:org_t)
- Cell Press, 2019
- 2019
- Engelska.
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Ingår i: Cell Stem Cell. - : Cell Press. - 1934-5909 .- 1875-9777. ; 24:4, s. 637-653.e9
- Relaterad länk:
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https://www.cell.com...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Increasing evidence suggests that cancer cells highjack developmental programs for disease initiation and progression. Melanoma arises from melanocytes that originate during development from neural crest stem cells (NCSCs). Here, we identified the transcription factor Yin Yang 1 (Yy1) as an NCSCs regulator. Conditional deletion of Yy1 in NCSCs resulted in stage-dependent hypoplasia of all major neural crest derivatives due to decreased proliferation and increased cell death. Moreover, conditional ablation of one Yy1 allele in a melanoma mouse model prevented tumorigenesis, indicating a particular susceptibility of melanoma cells to reduced Yy1 levels. Combined RNA sequencing (RNA-seq), chromatin immunoprecipitation (ChIP)-seq, and untargeted metabolomics demonstrated that YY1 governs multiple metabolic pathways and protein synthesis in both NCSCs and melanoma. In addition to directly regulating a metabolic gene set, YY1 can act upstream of MITF/c-MYC as part of a gene regulatory network controlling metabolism. Thus, both NCSC development and melanoma formation depend on an intricate YY1-controlled metabolic program.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- YY1
- development
- melanoma
- metabolism
- neural crest
- protein synthesis
- tumor initiation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Varum, Sandra
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Baggiolini, Aria ...
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Zurkirchen, Luis
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Atak, Zeynep Kal ...
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Cantù, Claudio, ...
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Marzorati, Elisa
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visa fler...
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Bossart, Raphaël
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Wouters, Jasper
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Häusel, Jessica
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Tuncer, Eylül
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Zingg, Daniel
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Veen, Dominiek
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John, Nessy
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Balz, Marcel
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Levesque, Mitche ...
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Basler, Konrad
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Aerts, Stein
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Zamboni, Nicola
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Dummer, Reinhard
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Sommer, Lukas
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Cell och molekyl ...
- Artiklar i publikationen
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Cell Stem Cell
- Av lärosätet
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Linköpings universitet