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LiQD Cornea: Pro-re...
LiQD Cornea: Pro-regeneration collagen mimetics as patches and alternatives to corneal transplantation
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- McTiernan, Christopher D. (author)
- Hop Maison Neuve Rosemont, Canada; Univ Montreal, Canada; Univ Montreal, Canada; Univ Ottawa, Canada
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- Simpson, Fiona C. (author)
- Hop Maison Neuve Rosemont, Canada; Univ Montreal, Canada; Univ Montreal, Canada
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- Haagdorens, Michel (author)
- Univ Antwerp, Belgium
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- Samarawickrama, Chameen (author)
- Linköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Univ Sydney, Australia
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- Hunter, Damien (author)
- Univ Sydney, Australia
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- Buznyk, Oleksiy (author)
- Linköpings universitet,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten,Region Östergötland, Ögonkliniken US
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- Fagerholm, Per (author)
- Linköpings universitet,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten,Region Östergötland, Ögonkliniken US
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- Kozak Ljunggren, Monika (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Lewis, Philip (author)
- Cardiff Univ, Wales
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- Pintelon, Isabel (author)
- Univ Antwerp, Belgium
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- Olsen, David (author)
- FibroGen Inc, CA USA
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- Edin, Elle (author)
- Hop Maison Neuve Rosemont, Canada; Univ Montreal, Canada; Univ Montreal, Canada
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- Groleau, Marc (author)
- Hop Maison Neuve Rosemont, Canada
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- Allan, Bruce D. (author)
- Moorfields Eye Hosp NHS Fdn Trust, England; UCL Inst Ophthalmol, England
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- Griffith, May (author)
- Hop Maison Neuve Rosemont, Canada; Univ Montreal, Canada; Univ Montreal, Canada
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(creator_code:org_t)
- AMER ASSOC ADVANCEMENT SCIENCE, 2020
- 2020
- English.
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In: Science Advances. - : AMER ASSOC ADVANCEMENT SCIENCE. - 2375-2548. ; 6:25
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://advances.sci...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Transplantation with donor corneas is the mainstay for treating corneal blindness, but a severe worldwide shortage necessitates the development of other treatment options. Corneal perforation from infection or inflammation is sealed with cyanoacrylate glue. However, the resulting cytotoxicity requires transplantation. LiQD Cornea is an alternative to conventional corneal transplantation and sealants. It is a cell-free, liquid hydrogel matrix for corneal regeneration, comprising short collagen-like peptides conjugated with polyethylene glycol and mixed with fibrinogen to promote adhesion within tissue defects. Gelation occurs spontaneously at body temperature within 5 min. Light exposure is not required-particularly advantageous because patients with corneal inflammation are typically photophobic. The self-assembling, fully defined, synthetic collagen analog is much less costly than human recombinant collagen and reduces the risk of immune rejection associated with xenogeneic materials. In situ gelation potentially allows for clinical application in outpatient clinics instead of operating theaters, maximizing practicality, and minimizing health care costs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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McTiernan, Chris ...
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Simpson, Fiona C ...
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Haagdorens, Mich ...
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Samarawickrama, ...
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Hunter, Damien
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Buznyk, Oleksiy
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show more...
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Fagerholm, Per
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Kozak Ljunggren, ...
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Lewis, Philip
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Pintelon, Isabel
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Olsen, David
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Edin, Elle
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Groleau, Marc
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Allan, Bruce D.
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Griffith, May
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Science Advances
- By the university
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Linköping University