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Brief Report: Diminished Coinhibitory Molecule 2B4 Expression Is Associated With Preserved iNKT Cell Phenotype in HIV Long-Term Nonprogressors

Ansari, Abdul W. (author)
Univ Malaya, Malaysia; Univ Sharjah, U Arab Emirates
Ahmad, Fareed (author)
Hannover Med Sch, Germany; Hamad Med Corp, Qatar; Hamad Med Corp, Qatar
Shankar, Esaki M. (author)
Univ Malaya, Malaysia; Cent Univ Tamil Nadu CUTN, India
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Yong, Yean K. (author)
Xiamen Univ Malaysia, Malaysia
Tan, Hong Y. (author)
Xiamen Univ Malaysia, Malaysia
Jacobs, Roland (author)
Hannover Med Sch, Germany
Larsson, Marie (author)
Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten
Velu, Vijayakumar (author)
Emory Vaccine Ctr & Immunol, GA USA
Kamarulzaman, Adeeba (author)
Univ Malaya, Malaysia
Schmidt, Reinhold E. (author)
Hannover Med Sch, Germany
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 (creator_code:org_t)
LIPPINCOTT WILLIAMS & WILKINS, 2020
2020
English.
In: Journal of Acquired Immune Deficiency Syndromes. - : LIPPINCOTT WILLIAMS & WILKINS. - 1525-4135 .- 1944-7884. ; 85:1, s. 73-78
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background: We have previously shown an association of elevated coinhibitory molecule 2B4 expression with iNKT cells alterations in HIV disease. Herein, we show a comparative analysis of 2B4 expression on iNKT cells of HIV long-term nonprogressors (LTNPs) and progressors. Methods: Antiretroviral therapy-naive HIV-seropositive individuals (progressors, n = 16) and LTNPs (n = 10) were recruited for this study. We used multicolor flow cytometry on frozen peripheral blood mononuclear cells to determine iNKT subset frequencies, the levels of coinhibitory 2B4 expression, and intracellular interferon-gamma (IFN-gamma) production. CD1d tetramer was used to characterize iNKT cells. Results: We report significantly lower level of 2B4 expression on bulk LTNPs iNKT cells and on their CD4 subsets compared with HIV progressors. Furthermore, the iNKT cells from LTNPs produced higher amount of IFN-gamma than HIV progressors as detected by intracellular cytokine staining. Interestingly, the frequency of 2B4(+)iNKT cells of progressors but not LTNPs significantly correlates with CD4 T-cell count, HIV viral load, and IFN-gamma(+)production by iNKT cells. Conclusion: Our results suggest that in addition to suppressed HIV replication, diminished 2B4 expression and associated coinhibitory signaling, and substantial production of IFN-gamma could contribute to preserved iNKT cell phenotype in LTNPs.

Subject headings

NATURVETENSKAP  -- Biologi -- Immunologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Immunology (hsv//eng)

Keyword

iNKT cells; CD4; HIV; LTNP; IFN-gamma

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