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Brief Report: Dimin...
Brief Report: Diminished Coinhibitory Molecule 2B4 Expression Is Associated With Preserved iNKT Cell Phenotype in HIV Long-Term Nonprogressors
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- Ansari, Abdul W. (author)
- Univ Malaya, Malaysia; Univ Sharjah, U Arab Emirates
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- Ahmad, Fareed (author)
- Hannover Med Sch, Germany; Hamad Med Corp, Qatar; Hamad Med Corp, Qatar
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- Shankar, Esaki M. (author)
- Univ Malaya, Malaysia; Cent Univ Tamil Nadu CUTN, India
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- Yong, Yean K. (author)
- Xiamen Univ Malaysia, Malaysia
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- Tan, Hong Y. (author)
- Xiamen Univ Malaysia, Malaysia
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- Jacobs, Roland (author)
- Hannover Med Sch, Germany
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- Larsson, Marie (author)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten
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- Velu, Vijayakumar (author)
- Emory Vaccine Ctr & Immunol, GA USA
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- Kamarulzaman, Adeeba (author)
- Univ Malaya, Malaysia
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- Schmidt, Reinhold E. (author)
- Hannover Med Sch, Germany
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(creator_code:org_t)
- LIPPINCOTT WILLIAMS & WILKINS, 2020
- 2020
- English.
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In: Journal of Acquired Immune Deficiency Syndromes. - : LIPPINCOTT WILLIAMS & WILKINS. - 1525-4135 .- 1944-7884. ; 85:1, s. 73-78
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: We have previously shown an association of elevated coinhibitory molecule 2B4 expression with iNKT cells alterations in HIV disease. Herein, we show a comparative analysis of 2B4 expression on iNKT cells of HIV long-term nonprogressors (LTNPs) and progressors. Methods: Antiretroviral therapy-naive HIV-seropositive individuals (progressors, n = 16) and LTNPs (n = 10) were recruited for this study. We used multicolor flow cytometry on frozen peripheral blood mononuclear cells to determine iNKT subset frequencies, the levels of coinhibitory 2B4 expression, and intracellular interferon-gamma (IFN-gamma) production. CD1d tetramer was used to characterize iNKT cells. Results: We report significantly lower level of 2B4 expression on bulk LTNPs iNKT cells and on their CD4 subsets compared with HIV progressors. Furthermore, the iNKT cells from LTNPs produced higher amount of IFN-gamma than HIV progressors as detected by intracellular cytokine staining. Interestingly, the frequency of 2B4(+)iNKT cells of progressors but not LTNPs significantly correlates with CD4 T-cell count, HIV viral load, and IFN-gamma(+)production by iNKT cells. Conclusion: Our results suggest that in addition to suppressed HIV replication, diminished 2B4 expression and associated coinhibitory signaling, and substantial production of IFN-gamma could contribute to preserved iNKT cell phenotype in LTNPs.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Keyword
- iNKT cells; CD4; HIV; LTNP; IFN-gamma
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ansari, Abdul W.
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Ahmad, Fareed
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Shankar, Esaki M ...
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Yong, Yean K.
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Tan, Hong Y.
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Jacobs, Roland
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Larsson, Marie
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Velu, Vijayakuma ...
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Kamarulzaman, Ad ...
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Schmidt, Reinhol ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
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Journal of Acqui ...
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Linköping University