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The Effect of Aniso...
The Effect of Anisotropy on the Impedance and Electric Field Distribution in Deep Brain Stimulation
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- Nordin, Teresa, 1987- (author)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,MINT
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- Wårdell, Karin, 1959- (author)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,MINT
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- Johansson, Johannes D., 1977- (author)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,MINT
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(creator_code:org_t)
- 2020-11-30
- 2020
- English.
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In: 8th European Medical and Biological Engineering Conference. - Cham : Springer. - 9783030646097 - 9783030646103 ; , s. 1069-1077
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Abstract
Subject headings
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- Deep brain stimulation (DBS) is an intervention used for several neurological conditions such as Parkinson’s disease. To evaluate the clinical response in relation to anatomical location, electric field simulation using the finite element method is commonly used. The models presented in different studies are varying in complexity and this study aims to evaluate the effect of including anisotropy in the tissue model using homogenous tissue with varying level of anisotropy both parallel and perpendicular to the DBS lead. As a benchmark, data from one patient was included and simulations was performed in zona incerta (Zi) and the internal capsule (IC). The parameters investigated were impedance, volume within the 0.2 V/mm isosurface, radial and longitudinal expansion as well as visual representation of the isosurface. The investigations show that both the impedance and volume are increasing with increasing anisotropy together with the electric field isosurface in the principal direction of the anisotropy. When comparing different stimulation modes, current control (CC) stimulation had a steeper increase with increasing anisotropy for all parameters compared to voltage control (VC) stimulation. This could be due to a joint effect of the anisotropy and the increasing impedance. The result from the patient simulations are in the anisotropy range where simulations from the homogenous models starts to have a higher slope for all parameters. This indicates that including anisotropy in computer models will be of importance in areas of high anisotropy.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Annan medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Other Medical Engineering (hsv//eng)
Keyword
- Electric field simulation
- Finite element method (FEM)
- Deep brain stimulation (DBS)
- Anisotropy Impedance
Publication and Content Type
- ref (subject category)
- kon (subject category)
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