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Global Differences in Burden and Treatment of Ischemic Heart Disease in Acute Heart Failure REPORT-HF

Tromp, Jasper (författare)
Natl Heart Ctr Singapore, Singapore; Duke NUS Med Sch Singapore, Singapore; Univ Med Ctr Groningen, Netherlands
Ouwerkerk, Wouter (författare)
Natl Heart Ctr Singapore, Singapore; Univ Amsterdam, Netherlands
Cleland, John G. F. (författare)
Univ Glasgow, Scotland; Imperial Coll, England
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Angermann, Christiane E. (författare)
Univ Wurzburg, Germany; Univ Hosp Wurzburg, Germany
Dahlström, Ulf (författare)
Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
Teng, Katherine Tiew-Hwa (författare)
Natl Heart Ctr Singapore, Singapore
Bamadhaj, Sahiddah (författare)
Natl Heart Ctr Singapore, Singapore
Ertl, Georg (författare)
Univ Wurzburg, Germany; Univ Hosp Wurzburg, Germany
Hassanein, Mahmoud (författare)
Alexandria Univ, Egypt
Perrone, Sergio V (författare)
El Cruce Hosp Florencio Varela, Argentina
Ghadanfar, Mathieu (författare)
M Ghadanfar Consulting Life Sci, Switzerland
Schweizer, Anja (författare)
Novartis Pharma AG, Switzerland
Obergfell, Achim (författare)
Novartis Pharma AG, Switzerland
Filippatos, Gerasimos (författare)
Univ Cyprus, Cyprus; Natl & Kapodistrian Univ Athens, Greece; Attikon Univ Hosp, Greece
Collins, Sean P. (författare)
Vanderbilt Univ, TN USA
Lam, Carolyn S. P. (författare)
Natl Heart Ctr Singapore, Singapore; Duke NUS Med Sch Singapore, Singapore
Dickstein, Kenneth (författare)
Univ Bergen, Norway
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 (creator_code:org_t)
ELSEVIER SCI LTD, 2021
2021
Engelska.
Ingår i: JACC. Heart failure. - : ELSEVIER SCI LTD. - 2213-1779 .- 2213-1787. ; 9:5, s. 349-359
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • OBJECTIVES The primary aim of the current study was to investigate global differences in prevalence, association with outcome, and treatment of ischemic heart disease (IHD) in patients with acute heart failure (AHF) in the REPORT-HF (International Registry to Assess Medical Practice With Longitudinal Observation for Treatment of Heart Failure) registry. BACKGROUND Data on IHD in patients with AHF are primarily from Western Europe and North America. Little is known about global differences in treatment and prognosis of patients with IHD and AHF. METHODS A total of 18,539 patients with AHF were prospectively enrolled from 44 countries and 365 centers in the REPORT-HF registry. Patients with a history of coronary artery disease, an ischemic event causing admission for AHF, or coronary revascularization were classified as IHD. Clinical characteristics, treatment, and outcomes of patients with and without IHD were explored. RESULTS Compared with 8,766 (47%) patients without IHD, 9,773 (53%) patients with IHD were older, more likely to have a left ventricular ejection fraction < 40% (heart failure with reduced ejection fraction [HFrEF]), and reported more comorbidities. IHD was more common in lower income compared with high-income countries (61% vs. 48%). Patients with IHD from countries with low health care expenditure per capita or without health insurance less likely underwent coronary revascularization or used anticoagulants at discharge. IHD was independently associated with worse cardiovascular death (hazard ratio: 1.21; 95% confidence interval: 1.09 to 1.35). The association between IHD and cardiovascular death was stronger in HFrEF compared with heart failure with preserved ejection fraction (p(interaction) <0.001). CONCLUSIONS In this large global contemporary cohort of patients with AHF, IHD was more common in low-income countries and conveyed worse 1-year mortality, especially in HFrEF. Patients in regions with the greatest burden of IHD were less likely to receive coronary revascularization and treatment for IHD. (C) 2021 by the American College of Cardiology Foundation.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

evidence-based pharmacotherapy; heart failure; ischemic heart disease; outcomes

Publikations- och innehållstyp

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