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Association of Long...
Association of Longitudinal High-Sensitivity Troponin T With Mortality in Patients With Chronic Kidney Disease
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- Chesnaye, Nicholas C. (author)
- Univ Amsterdam, Netherlands
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- Al-Sodany, Ehab (author)
- Karolinska Institutet,Karolinska Univ Hosp Huddinge, Sweden
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- Szummer, Karolina (author)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Barany, Peter (author)
- Karolinska Institutet,Karolinska Univ Hosp Huddinge, Sweden
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- Heimburger, Olof (author)
- Karolinska Institutet,Karolinska Univ Hosp Huddinge, Sweden
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- Almquist, Tora (author)
- Danderyd Hosp, Sweden
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- Melander, Stefan (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,Tallinn Univ Technol, Estonia
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- Uhlin, Fredrik (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US
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- Dekker, Friedo (author)
- Leiden Univ, Netherlands
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- Wanner, Christoph (author)
- Univ Hosp Wurzburg, Germany
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- Jager, Kitty J. (author)
- Univ Amsterdam, Netherlands
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- Evans, Marie (author)
- Karolinska Institutet,Karolinska Univ Hosp Huddinge, Sweden
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(creator_code:org_t)
- ELSEVIER SCIENCE INC, 2022
- 2022
- English.
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In: Journal of the American College of Cardiology. - : ELSEVIER SCIENCE INC. - 0735-1097 .- 1558-3597. ; 79:4, s. 327-336
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- BACKGROUND Cardiac troponin T (cTnT) is associated with mortality in chronic kidney disease (CKD). However, the association between longitudinal cTnT measurements and survival has not previously been assessed. OBJECTIVES This study determined whether various parameterizations of longitudinal cTnT measurements were associated with patient survival in the older population with advanced CKD. METHODS The EQUAL (European QUALity) study is an observational prospective cohort study that includes subjects with stage 4-5 CKD aged $65 years and not on dialysis. The study includes 176 participants in Sweden, where longitudinal information of cTnT was collected. The study uses joint models for longitudinal and time-to-event data to assess the longitudinal association between cTnT and survival. RESULTS There were 927 cTnT measurements (median 6 per patient) collected over a median follow-up of 2.4 years. The overall 5-year survival was 57% (95% CI: 46%-69%). Longitudinally measured cTnT was associated with mortality risk, with every SD increase in cTnT, at any time point, associated with a 3.3-fold increase in mortality risk (HR: 3.3; 95% CI: 2.5-4.6). The slope of the cTnT trajectory was also associated with increased mortality risk (HR: 3.2; 95% CI: 2.06.0), as was the area under the cTnT trajectory (HR: 4.2; 95% CI: 2.6-7.2), which reflected the cumulative cTnT exposure. CONCLUSIONS Longitudinally measured cTnT is independently associated with mortality risk in older patients with stage 4 and 5 CKD, which suggests that monitoring patients with cTnT could be a valuable tool for the identification of subjects with a high mortality risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- joint model; survival; troponin T; chronic kidney disease
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Chesnaye, Nichol ...
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Al-Sodany, Ehab
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Szummer, Karolin ...
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Barany, Peter
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Heimburger, Olof
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Almquist, Tora
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show more...
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Melander, Stefan
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Uhlin, Fredrik
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Dekker, Friedo
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Wanner, Christop ...
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Jager, Kitty J.
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Evans, Marie
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Journal of the A ...
- By the university
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Linköping University
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Karolinska Institutet