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Regulatory networks...
Regulatory networks and 5 partner usage of miRNA host gene fusions in breast cancer
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- Hafstað, Völundur (författare)
- Lund University,Lunds universitet,Experimentell onkologi,Forskargrupper vid Lunds universitet,Funktionell bröstcancergenomik,Experimental oncology,Lund University Research Groups,Functional Breast Cancer Genomics,Lund Univ, Sweden
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- Søkilde, Rolf (författare)
- Lund University,Lunds universitet,Experimentell onkologi,Forskargrupper vid Lunds universitet,Experimental oncology,Lund University Research Groups,Lund Univ, Sweden
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- Häkkinen, Jari (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Sweden
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- Larsson, Malin, 1977- (författare)
- Linköping University,Linköpings universitet,Bioinformatik,Tekniska fakulteten
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- Vallon-Christersson, Johan (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Sweden
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- Rovira, Carlos (författare)
- Lund University,Lunds universitet,Experimentell onkologi,Forskargrupper vid Lunds universitet,Experimental oncology,Lund University Research Groups,Lund Univ, Sweden
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- Persson, Helena (författare)
- Lund University,Lunds universitet,Experimentell onkologi,Forskargrupper vid Lunds universitet,Funktionell bröstcancergenomik,Bröst/ovarialcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Experimental oncology,Lund University Research Groups,Functional Breast Cancer Genomics,Breast/ovarian cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden
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(creator_code:org_t)
- 2022-02-26
- 2022
- Engelska.
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 151:1, s. 95-106
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- Genomic rearrangements in cancer cells can create gene fusions where the juxtaposition of two different genes leads to the production of chimeric proteins or altered gene expression through promoter-swapping. We have previously shown that fusion transcripts involving microRNA (miRNA) host genes contribute to deregulation of miRNA expression regardless of the protein-coding potential of these transcripts. Many different genes can also be used as 5 partners by a miRNA host gene in what we named recurrent miRNA-convergent fusions. Here, we have explored the properties of 5 partners in fusion transcripts that involve miRNA hosts in breast tumours from The Cancer Genome Atlas (TCGA). We hypothesised that firstly, 5 partner genes should belong to pathways and transcriptional programmes that reflect the tumour phenotype and secondly, there should be a selection for fusion events that shape miRNA expression to benefit the tumour cell through the known hallmarks of cancer. We found that the set of 5 partners in miRNA host fusions is non-random, with overrepresentation of highly expressed genes in pathways active in cancer including epithelial-to-mesenchymal transition, translational regulation and oestrogen signalling. Furthermore, many miRNAs were upregulated in samples with host gene fusions, including established onco-genic miRNAs such as mir-21 and the mir-106b similar to mir-93 similar to mir-25 cluster. To the list of mechanisms for deregulation of miRNA expression, we have added fusion transcripts that change the promoter region. We propose that this adds material for genetic selection and tumour evolution in cancer cells and that miRNA host fusions can act as tumour drivers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- breast cancer; fusion gene; fusion transcript; microRNA
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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