Accumulation of 10B in human synovial sarcoma cells in vitro for possible use in BNCT

• Synovial sarcoma is a distinct tumour with unique promise for targeted therapy. Due to the location and characteristics, boron neutron capture therapy (BNCT) might be an interesting alternative treatment regimen. The binary method utilizes the ionizing effects of high energy short-ranged fission particles produced after the capturing of neutrons by stable 10B. This study reports results regarding the accumulation of 10B administered as boronophenylalanine (BPA) in a human synovial sarcoma cell line (4SS) in vitro. 4SS cells were incubated in BPAcontaining cell culture medium and cell-associated boron was analysed using inductively coupled plasma atomic emission spectroscopy (ICP-AES). The results show that 4SS cells accumulate boron in a clinical relevant concentration range. Further investigations may state the potential of BNCT as a treatment modality for synovial sarcomas and explore the possibilities of a directed delivery of boron-containing substances to receptors specifically expressed in this malignancy.

Nyckelord

Synovial sarcoma

boron neutron capture therapy

BNCT

boronophenylalanine

BPA

targeting

4SS

in vitro

cell culture

cell-associated boron

MEDICINE

MEDICIN

Publikations- och innehållstyp

vet (ämneskategori)

ovr (ämneskategori)